Microbiome for Mars: surveying microbiome connections to healthcare with implications for long-duration human spaceflight, virtual workshop, July 13, 2020

Michael LaPelusa; Dorit Donoviel; Sergio E Branzini; Paul E Carlson Jr; Stephanie Culler; Amrita K Cheema; Rima Kaddurah-Daouk; Denise Kelly; Isabelle de Cremoux; Rob Knight; Rosa Krajmalnik-Brown; Stephen L Mayo; Sarkis K Mazmanian; Emeran A Mayer; Joseph F Petrosino; Keith Garrison

doi:10.1186/s40168-020-00951-5

Microbiome for Mars: surveying microbiome connections to healthcare with implications for long-duration human spaceflight, virtual workshop, July 13, 2020

Microbiome. 2021 Jan 4;9(1):2. doi: 10.1186/s40168-020-00951-5.

Authors

Michael LaPelusa¹, Dorit Donoviel², Sergio E Branzini³, Paul E Carlson Jr⁴, Stephanie Culler⁵, Amrita K Cheema⁶, Rima Kaddurah-Daouk⁷, Denise Kelly⁸, Isabelle de Cremoux⁸, Rob Knight⁹, Rosa Krajmalnik-Brown^{10

11}, Stephen L Mayo¹², Sarkis K Mazmanian¹², Emeran A Mayer^{13

14

15}, Joseph F Petrosino¹⁶, Keith Garrison¹⁷

Affiliations

¹ Department of Medicine, Vanderbilt University Medical Center, One Hundred Oaks - North 719 Thompson Lane Suite 20400, Nashville, TN, 37204, USA. michael.lapelusa@vumc.org.
² Department of Pharmacology and Chemical Biology, Center for Space Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.
³ Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, 94158, USA.
⁴ Laboratory of Mucosal Pathogens and Cellular Immunology, Division of Bacterial, Parasitic, and Allergenic Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Silver Spring, MD, 20993, USA.
⁵ Persephone Biosciences Inc, JLABS, 3210 Merryfield Row, San Diego, CA, 92121, USA.
⁶ Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, 20007, USA.
⁷ Department of Psychiatry and Behavioral Sciences, Department of Medicine and the Duke Institute for Brain Sciences, Duke University, Durham, NC, 27708, USA.
⁸ Seventure Partners, 5-7 rue de Monttessuy, 75340 Cedex 07, Paris, France.
⁹ Departments of Pediatrics, Bioengineering, and Computer Science & Engineering, University of California San Diego, 9500 Gilman Drive, MC 0763, La Jolla, CA, 92093-0763, USA.
¹⁰ Biodesign Center for Health Through Microbiomes, Arizona State University, Tempe, AZ, USA.
¹¹ School of Sustainable Engineering and the Built Environment, Arizona State University, Tempe, AZ, USA.
¹² Division of Biology and Biological Engineering, California Institute of Technology, 1200 E. California Bl, Pasadena, CA, 91125, USA.
¹³ G. Oppenheimer Family Center for Neurobiology of Stress and Resilience, Ingestive Behavior and Obesity Program, University of California Los Angeles, Los Angeles, CA, USA.
¹⁴ Vatche and Tamar Manoukian Division of Digestive Diseases, University of California Los Angeles, Los Angeles, CA, USA.
¹⁵ David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
¹⁶ Department of Molecular Virology and Microbiology, Alkek Center for Metagenomics and Microbiome Research, Baylor College of Medicine, Houston, Texas, USA.
¹⁷ Department of Medicine, The University of Texas at Houston Health Sciences Center, 6431 Fannin St, Houston, TX, 77030, USA. Keith.R.Garrison@uth.tmc.edu.

Abstract

The inaugural "Microbiome for Mars" virtual workshop took place on July 13, 2020. This event assembled leaders in microbiome research and development to discuss their work and how it may relate to long-duration human space travel. The conference focused on surveying current microbiome research, future endeavors, and how this growing field could broadly impact human health and space exploration. This report summarizes each speaker's presentation in the order presented at the workshop.

Keywords: Autism spectrum disorder; Behavior; Fecal microbiota transplants; Gut-brain axis; Live biotherapeutic products; Metabolome; Microbiome; Multiple sclerosis; Radiation; Sequencing; Spaceflight.

Publication types

Congress
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Astronauts*
Delivery of Health Care / trends*
Gastrointestinal Microbiome / genetics
Gastrointestinal Microbiome / physiology
Humans
Mars*
Microbiota / genetics
Microbiota / physiology*
Space Flight*