Identifying factors influencing mortality in patients aged over 65 following an acute type II odontoid process fracture. A retrospective cohort study

Eur Spine J. 2021 Jun;30(6):1551-1555. doi: 10.1007/s00586-020-06694-z. Epub 2021 Feb 22.

Abstract

Objective: Compare short-term mortality rates following operative and nonoperative management of geriatric patients following an acute type II odontoid process fracture.

Methods: One hundred forty-one patients with a type II odontoid fracture were identified from a single centre between 2002 and 2018. Patient demographics, details of injury and management, plus mortality data were collected. The incidence of mortality at 3 and 12 months was calculated, and a multivariate model built which included the treatment modality variable and allowed adjustment for six individual confounders.

Results: Of the 141 patients with a type II odontoid process fracture, 39 were managed operatively, while 102 were managed nonoperatively. Relative to the nonoperative group, the operative group was younger (79.0 ± 7.0 vs. 83.7 ± 7.6), more likely to have odontoid angulation > 15° (74.4% vs. 43.1%, p < 0.01), and a greater proportion having fracture displacement > 2 mm (74.4% vs. 31.4%, p < 0.01). Both groups were comparable for gender, comorbidities, and associated injuries. On univariate analysis of treatment modality, the odds ratio of 3-month mortality with nonoperative management was 2.55 (95% CI: 0.82-7.92; p = 0.08), whilst at 12-months it was 3.12 (95% CI: 1.11-8.69; p = 0.02). On multivariate analysis of 12-month mortality, however, treatment modality was not found to be significant. This multivariate analysis suggested that increasing age, male gender, and injury severity were significant predictors of 12-month mortality.

Conclusion: In contrast to the findings of a number of previous studies, operative management may not influence survival at 3- and 12-months.

Keywords: Aged; Mortality; Odontoid process; Spinal fracture.

MeSH terms

  • Aged
  • Fractures, Bone*
  • Humans
  • Incidence
  • Male
  • Odontoid Process* / injuries
  • Retrospective Studies
  • Spinal Fractures* / therapy
  • Treatment Outcome