FPR-1 (Formyl Peptide Receptor-1) Activation Promotes Spontaneous, Premature Hypertension in Dahl Salt-Sensitive Rats

Hypertension. 2021 Apr;77(4):1191-1202. doi: 10.1161/HYPERTENSIONAHA.120.16237. Epub 2021 Mar 1.

Abstract

[Figure: see text].

Keywords: hypertension; microbiota; mitochondria; rats, inbred Dahl; vascular remodelling.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Bacterial Physiological Phenomena
  • Blood Pressure / physiology*
  • Cell Death / physiology*
  • Gastrointestinal Microbiome / physiology*
  • Hypertension* / metabolism
  • Hypertension* / physiopathology
  • Mitochondria / physiology*
  • Rats
  • Rats, Inbred Dahl
  • Receptors, Formyl Peptide / metabolism
  • Sodium Chloride, Dietary / metabolism
  • Vascular Remodeling / physiology

Substances

  • Fpr1 protein, rat
  • Receptors, Formyl Peptide
  • Sodium Chloride, Dietary