Genetics of canine diabetes mellitus part 2: Current understanding and future directions

Vet J. 2021 Apr:270:105612. doi: 10.1016/j.tvjl.2021.105612. Epub 2021 Jan 15.

Abstract

Part 1 of this 2-part review outlined the importance of disease classification in diabetes genetic studies, as well as the ways in which genetic variants may contribute to risk of a complex disease within an individual, or within a particular group of individuals. Part 2, presented here, describes in more detail our current understanding of the genetics of canine diabetes mellitus compared to our knowledge of the human disease. Ongoing work to improve our knowledge, using new technologies, is also introduced.

Keywords: Canine; Diabetes mellitus; Genetics; Genomics; Major histocompatibility complex.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Animals
  • Diabetes Mellitus / classification
  • Diabetes Mellitus / genetics
  • Diabetes Mellitus / veterinary*
  • Diabetes Mellitus, Type 1 / genetics
  • Diabetes Mellitus, Type 1 / immunology
  • Dog Diseases / classification
  • Dog Diseases / genetics*
  • Dog Diseases / immunology
  • Dogs
  • Genetic Predisposition to Disease / genetics*
  • HLA Antigens / genetics
  • HLA Antigens / immunology
  • High-Throughput Nucleotide Sequencing / veterinary
  • Humans
  • Immunity / genetics
  • Insulin-Secreting Cells / immunology
  • Major Histocompatibility Complex / genetics
  • Mutation

Substances

  • HLA Antigens