Genome-Wide Association Study and Identification of a Protective Missense Variant on Lipoprotein(a) Concentration: Protective Missense Variant on Lipoprotein(a) Concentration-Brief Report

Arterioscler Thromb Vasc Biol. 2021 May 5;41(5):1792-1800. doi: 10.1161/ATVBAHA.120.315300. Epub 2021 Mar 18.

¹ Department of Cardiology (M.A.S., M.W.Y., Y.J.v.d.V., J.W.B., L.E.J.-O., N.V., P.v.d.H.), University Medical Center Groningen, University of Groningen, the Netherlands.
² Department of Endocrinology (R.P.F.D.), University Medical Center Groningen, University of Groningen, the Netherlands.
³ Institute for Molecular Medicine Finland HiLIFE (S. Ruotsalainen, S. Ripatti), University of Helsinki, Finland.
⁴ Department of Public Health (S. Ripatti), University of Helsinki, Finland.
⁵ Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA (S. Ripatti, P.N.).
⁶ Department of Medicine, Harvard Medical School, Boston, MA (P.N.).
⁷ Cardiovascular Research Center, Massachusetts General Hospital, Boston (P.N.).
⁸ Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, University of Utrecht, the Netherlands (L.E.J.-O., P.v.d.H.).

Abstract

[Figure: see text].

Keywords: causality; coronary artery disease; genetics; lipoproteins; polymorphism, single nucleotide.