Discrepancies of polygenic effects on symptom dimensions between adolescents and adults with ADHD

Wenhao Jiang; Kelly Rootes-Murdy; Kuaikuai Duan; Gido Schoenmacker; Pieter J Hoekstra; Catharina A Hartman; Jaap Oosterlaan; Dirk Heslenfeld; Barbara Franke; Emma Sprooten; Jan Buitelaar; Alejandro Arias-Vasquez; Jingyu Liu; Jessica A Turner

doi:10.1016/j.pscychresns.2021.111282

Discrepancies of polygenic effects on symptom dimensions between adolescents and adults with ADHD

Psychiatry Res Neuroimaging. 2021 May 30:311:111282. doi: 10.1016/j.pscychresns.2021.111282. Epub 2021 Mar 20.

Authors

Affiliations

¹ Department of Psychology, Georgia State University, United States; Department of Psychosomatics and Psychiatry, Zhongda Hospital, Institute of Psychosomatics, Medical School, Southeast University, Nanjing, China.
² Department of Psychology, Georgia State University, United States. Electronic address: krootesmurdy1@student.gsu.edu.
³ School of Electrical and Computer Engineering, Georgia Institute of Technology, USA.
⁴ Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
⁵ University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, the Netherlands.
⁶ Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Emma Neuroscience Group, department of Pediatrics, Amsterdam Reproduction & Development, Amsterdam, The Netherlands; Vrije Universiteit, Clinical Neuropsychology section, Van der Boechortstraat 7, 1081 BT Amsterdam, Netherlands.
⁷ Vrije Universiteit, Clinical Neuropsychology section, Van der Boechortstraat 7, 1081 BT Amsterdam, Netherlands.
⁸ Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
⁹ Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
¹⁰ Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology and Emory University, USA; Department of Computer Science, Georgia State University, USA.
¹¹ Department of Psychology, Georgia State University, United States; Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology and Emory University, USA; Neuroscience Institute, Georgia State University, USA.

Abstract

A significant proportion of individuals with attention-deficit/hyperactivity disorder (ADHD) show persistence into adulthood. The genetic and neural correlates of ADHD in adolescents versus adults remain poorly characterized. We investigated ADHD polygenic risk score (PRS) in relation to previously identified gray matter (GM) patterns, neurocognitive, and symptom findings in the same ADHD sample (462 adolescents & 422 adults from the NeuroIMAGE and IMpACT cohorts). Significant effects of ADHD PRS were found on hyperactivity and impulsivity symptoms in adolescents, hyperactivity symptom in adults, but not GM volume components. A distinct PRS effect between adolescents and adults on individual ADHD symptoms is suggested.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Attention
Attention Deficit Disorder with Hyperactivity* / genetics
Gray Matter
Humans
Impulsive Behavior
Multifactorial Inheritance / genetics

Abstract

Publication types

MeSH terms

Grants and funding