Association Between Genetic Variation in Blood Pressure and Increased Lifetime Risk of Peripheral Artery Disease

Michael G Levin; Derek Klarin; Venexia M Walker; Dipender Gill; Julie Lynch; Jacklyn N Hellwege; Jacob M Keaton; Kyung M Lee; Themistocles L Assimes; Pradeep Natarajan; Adriana M Hung; Todd L Edwards; Daniel J Rader; J Michael Gaziano; Neil M Davies; Philip S Tsao; Kyong-Mi Chang; Benjamin F Voight; Scott M Damrauer; VA Million Veteran Program

doi:10.1161/ATVBAHA.120.315482

Association Between Genetic Variation in Blood Pressure and Increased Lifetime Risk of Peripheral Artery Disease

Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):2027-2034. doi: 10.1161/ATVBAHA.120.315482. Epub 2021 Apr 15.

Authors

Michael G Levin^{1

2

3}, Derek Klarin^{4

5}, Venexia M Walker⁶, Dipender Gill^{7

8

9

10

11}, Julie Lynch^{12

13}, Jacklyn N Hellwege^{14

15}, Jacob M Keaton^{16

17}, Kyung M Lee^{3

13

18

19}, Themistocles L Assimes^{20

21

22}, Pradeep Natarajan^{23

24

25

26}, Adriana M Hung²⁷, Todd L Edwards²⁸, Daniel J Rader^{2

29

30}, J Michael Gaziano^{31

26}, Neil M Davies^{6

32}, Philip S Tsao^{20

21

22}, Kyong-Mi Chang², Benjamin F Voight^{29

30

33

3}, Scott M Damrauer^{34

3}; VA Million Veteran Program

Affiliations

¹ Division of Cardiovascular Medicine (M.G.L.), University of Pennsylvania Perelman School of Medicine, Philadelphia.
² Department of Medicine (M.G. L., D.J.R., K.-M.C.), University of Pennsylvania Perelman School of Medicine, Philadelphia.
³ Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA (M.G.L., K.-M.C., B.F.V., S.M.D.).
⁴ Malcolm Randall VA Medical Center, Gainesville, FL (D.K.).
⁵ Department of Surgery, University of Florida, Gainesville (D.K.).
⁶ Medical Research Council Integrative Epidemiology Unit, University of Bristol, United Kingdom (V.M.W., N.M.D.).
⁷ Department of Epidemiology and Biostatistics, School of Public Health (D.G.), Imperial College London, United Kingdom.
⁸ Department of Medicine, Centre for Pharmacology and Therapeutics, Hammersmith Campus (D.G.), Imperial College London, United Kingdom.
⁹ Novo Nordisk Research Centre Oxford, Old Road Campus, United Kingdom (D.G.).
¹⁰ Clinical Pharmacology and Therapeutics Section, Institute of Medical and Biomedical Education and Institute for Infection and Immunity, St George's, University of London, United Kingdom (D.G.).
¹¹ Clinical Pharmacology Group, Pharmacy and Medicines Directorate, St George's University Hospitals NHS Foundation Trust, London, United Kingdom (D.G.).
¹² Edith Nourse VA Medical Center, Bedford, MA (J.L.).
¹³ VA Informatics and Computing Infrastructure, Department of Veterans Affairs, Salt Lake City Health Care System, CT (J.L., K.M.L.).
¹⁴ Division of Genetic Medicine, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center (J.N.H.), Vanderbilt University Medical Center, Nashville, TN.
¹⁵ Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN (J.N.H.).
¹⁶ Division of Epidemiology, Department of Medicine (J.M.K.), Vanderbilt University Medical Center, Nashville, TN.
¹⁷ Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD (J.M.K.).
¹⁸ Center for Healthcare Organization and Implementation Research, Edith Nourse Rogers Memorial VA Hospital, Bedford, MA (K.M.L.).
¹⁹ Department of Health Law, Policy and Management, Boston University School of Public Health, MA (K.M.L.).
²⁰ Palo Alto VA Healthcare System, CA (T.L.A., P.S.T.).
²¹ Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, CA (T.L.A., P.S.T.).
²² Stanford Cardiovascular Institute, Stanford University, CA (T.L.A., P.S.T.).
²³ Cardiovascular Research Center, Massachusetts General Hospital, Boston (P.N.).
²⁴ Broad Institute of Harvard and MIT, Cambridge, MA (P.N.).
²⁵ Department of Medicine (P.N.).
²⁶ VA Boston Healthcare System, MA (P.N., J.M.G.).
²⁷ Division of Nephrology and Hypertension, Department of Medicine (A.M.H.), Vanderbilt University Medical Center, Nashville, TN.
²⁸ Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute (T.L.E.), Vanderbilt University Medical Center, Nashville, TN.
²⁹ Department of Genetics (D.J.R., B.F.V.), University of Pennsylvania Perelman School of Medicine, Philadelphia.
³⁰ Institute for Translational Medicine and Therapeutics (D.J.R., B.F.V.), University of Pennsylvania Perelman School of Medicine, Philadelphia.
³¹ Division of Aging, Department of Preventive Medicine, Brigham and Women's Hospital (J.M.G.), Harvard Medical School, Boston, MA.
³² K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Norway (N.M.D.).
³³ Department of Systems Pharmacology and Translational Therapeutics (B.F.V.), University of Pennsylvania Perelman School of Medicine, Philadelphia.
³⁴ Department of Surgery (S.M.D.), University of Pennsylvania Perelman School of Medicine, Philadelphia.

Abstract

[Figure: see text].

Keywords: atherosclerosis; blood pressure; coronary artery disease; peripheral artery disease; risk factors.

Publication types

Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Antihypertensive Agents / therapeutic use
Blood Pressure* / drug effects
Blood Pressure* / genetics
Databases, Factual
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Hypertension* / drug therapy
Hypertension* / ethnology
Hypertension* / genetics
Hypertension* / physiopathology
Mendelian Randomization Analysis
Multicenter Studies as Topic
Peripheral Arterial Disease* / ethnology
Peripheral Arterial Disease* / genetics
Peripheral Arterial Disease* / physiopathology
Peripheral Arterial Disease* / prevention & control
Phenotype
Polymorphism, Single Nucleotide*
Protective Factors
Risk Assessment
Risk Factors
United Kingdom / epidemiology
United States / epidemiology

Substances

Antihypertensive Agents

Abstract

Publication types

MeSH terms

Substances

Grants and funding