Interventions and symptom relief in hospital palliative cancer care: results from a prospective longitudinal study

Support Care Cancer. 2021 Nov;29(11):6595-6603. doi: 10.1007/s00520-021-06248-z. Epub 2021 May 3.

Abstract

Purpose: To study the use of interventions and symptom relief for adult patients with incurable cancer admitted to an acute palliative care unit providing integrated oncology and palliative care services.

Methods: All admissions during 1 year were assessed. The use of interventions was evaluated for all hospitalizations. Patients with assessments for worst and average pain intensity, tiredness, drowsiness, nausea, appetite, dyspnea, depression, anxiety, well-being, constipation, and sleep were evaluated for symptom development during hospitalization. Descriptive statistics was applied for the use of interventions and the paired sample t-test to compare symptom intensities (SIs).

Results: For 451 admissions, mean hospital length of stay was 7.0 days and mean patient age 69 years. More than one-third received systemic cancer therapy. Diagnostic imaging was performed in 66% of the hospitalizations, intravenous rehydration in 45%, 37% received antibiotics, and 39% were attended by the multidisciplinary team. At admission and at discharge, respectively, 55% and 44% received oral opioids and 27% and 45% subcutaneous opioids. For the majority, opioid dose was adjusted during hospitalization. Symptom registrations were available for 180 patients. Tiredness yielded the highest mean SI score (5.6, NRS 0-10) at admission and nausea the lowest (2.2). Significant reductions during hospitalization were reported for all assessed SIs (p ≤ 0.01). Patients receiving systemic cancer therapy reported symptom relief similar to those not on systemic cancer therapy.

Conclusion: Clinical practice and symptom relief during hospitalization were described. Symptom improvements were similar for oncological and palliative care patients.

Keywords: Acute palliative care unit (APCU); Cancer; Integration; Palliative; Symptom development; Symptoms.

MeSH terms

  • Adult
  • Hospitals
  • Humans
  • Infant, Newborn
  • Longitudinal Studies
  • Neoplasms* / complications
  • Neoplasms* / therapy
  • Palliative Care*
  • Prospective Studies