Diabetes and Osteoporosis: Part I, Epidemiology and Pathophysiology

G Isanne Schacter; William D Leslie

doi:10.1016/j.ecl.2021.03.005

Diabetes and Osteoporosis: Part I, Epidemiology and Pathophysiology

Endocrinol Metab Clin North Am. 2021 Jun;50(2):275-285. doi: 10.1016/j.ecl.2021.03.005. Epub 2021 Apr 28.

Authors

G Isanne Schacter¹, William D Leslie²

Affiliations

¹ Department of Medicine, Rady Faculty of Health Sciences, University of Manitoba, GF-335, 820 Sherbrook Street, Winnipeg, Manitoba R3A 1R9, Canada.
² Department of Medicine, Rady Faculty of Health Sciences, University of Manitoba, C5121, 409 Tache Avenue, Winnipeg, Manitoba R2H 2A6, Canada. Electronic address: bleslie@sbgh.mb.ca.

PMID: 34023043
DOI: 10.1016/j.ecl.2021.03.005

Abstract

Both diabetes and osteoporosis are increasingly prevalent diseases, in part owing to aging populations worldwide. Epidemiologic data have shown that other organs may be adversely affected by diabetes, including the skeleton, in what has become known as diabetes-induced osteoporosis, which represents the combined impact of conventional osteoporosis with the additional fracture burden attributed to diabetes. There is an increased risk of fracture in patients with Type 1 and Type 2 diabetes, and some antidiabetic medications also may contribute to increased risk of fracture in diabetes.

Keywords: Bone; Bone mineral density; Diabetes; Dual-energy x-ray absorptiometry; Fracture; Osteoporosis.

Publication types

Review

MeSH terms

Absorptiometry, Photon
Bone Density
Diabetes Mellitus, Type 2* / complications
Diabetes Mellitus, Type 2* / epidemiology
Fractures, Bone* / epidemiology
Fractures, Bone* / etiology
Humans
Osteoporosis* / epidemiology
Osteoporosis* / etiology