A Review of Clinical Trials That Contributed to Chronic Obstructive Pulmonary Disease Treatment Protocols

Jude ElSaygh; Anas Zaher; Pratiksha Nathani; Mohamed Omballi

doi:10.7759/cureus.14618

A Review of Clinical Trials That Contributed to Chronic Obstructive Pulmonary Disease Treatment Protocols

Cureus. 2021 Apr 21;13(4):e14618. doi: 10.7759/cureus.14618.

Authors

Jude ElSaygh¹, Anas Zaher¹, Pratiksha Nathani², Mohamed Omballi³

Affiliations

¹ Internal Medicine, University of Debrecen, Debrecen, HUN.
² Internal Medicine, Maharashtra University of Health Sciences, Latur, IND.
³ Pulmonary and Critical Care Medicine, The University of Toledo, Toledo, USA.

Abstract

Chronic obstructive pulmonary disease (COPD) has remained a leading cause of death worldwide and is expected to increase its burden on the healthcare system in the coming future. Numerous clinical trials have been conducted over the years and as a result, many drugs became a part of the treatment protocols of COPD. Currently, there are also several drugs under development. This review will help future researchers to grasp salient features of previous studies and use them in their future trials in order to reduce the morbidity and mortality of COPD. Randomized control trials provide strong evidence for any hypothesis in a research study. This review focuses on major COPD trials in the last two decades including TORCH, UPLIFT, POET, WISDOM, and TIOSPIR. It showcases the main clinical question, primary outcome, and result of these five trials.

Keywords: copd; obstructive lung disease; poet; rct; salmeterol; tiotropium; torch; uplift; wisdom.

Publication types

Review