Consensus statement on normothermic regional perfusion in donation after circulatory death: Report from the European Society for Organ Transplantation's Transplant Learning Journey

Ina Jochmans; Amelia J Hessheimer; Arne P Neyrinck; David Paredes; Maria Irene Bellini; John H Dark; Hendrikus J A N Kimenai; Liset H M Pengel; Christopher J E Watson; ESOT Workstream 04 of the TLJ (Transplant Learning Journey) project

doi:10.1111/tri.13951

Consensus statement on normothermic regional perfusion in donation after circulatory death: Report from the European Society for Organ Transplantation's Transplant Learning Journey

Transpl Int. 2021 Nov;34(11):2019-2030. doi: 10.1111/tri.13951.

Collaborators

ESOT Workstream 04 of the TLJ (Transplant Learning Journey) project:
Massimo Abelli, Corinne Antoine, Benoît Barrou, Irene Bello, Karlien Degezelle, Julie De Beule, Riccado De Carlis, Jeroen de Jonge, Stein Foss, Volkert A L Huurman, Simon R Knight, Guillaume Lebreton, Didier Ledoux, Alex Manara, Eduardo Miñambres, Filip Rega, Antonio Rubino, Marian Ryan, Edouard Sage, Eric Savier, Paul Schotsmans, Elena Ticozelli, Katrien Vandendriessche, Marinella Zanierato

Affiliations

¹ Transplantation Research Group, Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium.
² Department of Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium.
³ Department of General & Digestive Surgery, Institut Clínic de Malalties Digestives i Metabòliques (ICMDM), Hospital Clínic, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain.
⁴ Anesthesiology and Algology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
⁵ Department of Anesthesiology, University Hospitals Leuven, Leuven, Belgium.
⁶ Donation and Transplant Coordination Unit, Hospital Clínic Barcelona, University of Barcelona, Barcelona, Spain.
⁷ Department of Emergency Medicine and Surgery, Azienda Ospedaliera San Camillo Forlanini, Rome, Italy.
⁸ Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, UK.
⁹ Division of Transplant Surgery, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
¹⁰ Nuffield Department of Surgical Sciences, Centre for Evidence in Transplantation, University of Oxford, Oxford, UK.
¹¹ Department of Surgery, Addenbrooke's Hospital, Cambridge, UK.
¹² NIHR Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK.

PMID: 34145644
DOI: 10.1111/tri.13951

Abstract

Normothermic regional perfusion (NRP) in donation after circulatory death (DCD) is a safe alternative to in situ cooling and rapid procurement. An increasing number of countries and centres are performing NRP, a technically and logistically challenging procedure. This consensus document provides evidence-based recommendations on the use of NRP in uncontrolled and controlled DCDs. It also offers minimal ethical, logistical and technical requirements that form the foundation of a safe and effective NRP programme. The present article is based on evidence and opinions formulated by a panel of European experts of Workstream 04 of the Transplantation Learning Journey project, which is part of the European Society for Organ Transplantation.

Keywords: donation after circulatory death; guidelines; normothermic regional perfusion; solid organ transplantation.

MeSH terms

Consensus
Death
Humans
Organ Preservation
Organ Transplantation*
Perfusion
Tissue Donors
Tissue and Organ Procurement*

Grants and funding

European Society for Organ Transplantation