Connecting Cholesterol Efflux Factors to Lung Cancer Biology and Therapeutics

Int J Mol Sci. 2021 Jul 5;22(13):7209. doi: 10.3390/ijms22137209.

Abstract

Cholesterol is a foundational molecule of biology. There is a long-standing interest in understanding how cholesterol metabolism is intertwined with cancer biology. In this review, we focus on the known connections between lung cancer and molecules mediating cholesterol efflux. A major take-home lesson is that the roles of many cholesterol efflux factors remain underexplored. It is our hope that this article would motivate others to investigate how cholesterol efflux factors contribute to lung cancer biology.

Keywords: ABCA1; ABCG1; Apo AI; LAL; LRPs; NCEH1; NPC1; SMPD1; SR-BI; STARD3; TTF-1; cholesterol efflux; cisplatin; drug resistance; lung cancer; miR-200b-3p; miR-33a; miRNA.

Publication types

  • Review

MeSH terms

  • ATP Binding Cassette Transporter 1 / genetics
  • ATP Binding Cassette Transporter 1 / metabolism
  • ATP Binding Cassette Transporter, Subfamily G, Member 1 / genetics
  • ATP Binding Cassette Transporter, Subfamily G, Member 1 / metabolism
  • ATP-Binding Cassette Transporters / genetics
  • ATP-Binding Cassette Transporters / metabolism*
  • Animals
  • Apolipoprotein A-I / genetics
  • Apolipoprotein A-I / metabolism
  • Biological Transport, Active
  • Cholesterol / metabolism*
  • Humans
  • LDL-Receptor Related Proteins / genetics
  • LDL-Receptor Related Proteins / metabolism
  • Lung Neoplasms / genetics
  • Lung Neoplasms / metabolism*
  • Lung Neoplasms / therapy
  • MicroRNAs / genetics
  • MicroRNAs / metabolism
  • Models, Biological

Substances

  • ABCA1 protein, human
  • ABCG1 protein, human
  • ATP Binding Cassette Transporter 1
  • ATP Binding Cassette Transporter, Subfamily G, Member 1
  • ATP-Binding Cassette Transporters
  • Apolipoprotein A-I
  • LDL-Receptor Related Proteins
  • MicroRNAs
  • Cholesterol