Immune-Related Gene Expression Analysis Revealed Three lncRNAs as Prognostic Factors for Colon Cancer

Xiao-Liang Xing; Ti Zhang; Zhi-Yong Yao; Chaoqun Xing; Chunxiao Wang; Yuan-Wu Liu; Minjiang Huang

doi:10.3389/fgene.2021.690053

Immune-Related Gene Expression Analysis Revealed Three lncRNAs as Prognostic Factors for Colon Cancer

Front Genet. 2021 Jul 9:12:690053. doi: 10.3389/fgene.2021.690053. eCollection 2021.

Authors

Xiao-Liang Xing¹, Ti Zhang¹, Zhi-Yong Yao¹, Chaoqun Xing¹, Chunxiao Wang¹, Yuan-Wu Liu², Minjiang Huang¹

Affiliations

¹ School of Public Health and Laboratory Medicine, Hunan University of Medicine, Huaihua, China.
² Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing, China.

Abstract

Colorectal cancer (CRC) is one of the most common cancers. Almost 80% of CRC cases are colon adenocarcinomas (COADs). Several studies have indicated the role of immunotherapy in the treatment of various cancers. Our study aimed to identify immune-related long non-coding RNAs (lncRNAs) and to use them to construct a risk assessment model for evaluating COAD prognosis. Using differential expression, correlation, and Cox regression analyses, we identified three immune-related differentially expressed lncRNAs (IR-DELs) and used them to construct a risk assessment model. The area under the curve (AUC) for each receiver operating characteristic (ROC) curve at 3-, 5-, and 10-years were greater than 0.6. In addition, the risk assessment model was correlated with several immune cells and factors. The three IR-DELs (AC124067.4, LINC02604, and MIR4435-2HG) identified in this study can be used to predict outcomes for patients with COAD and might help in identifying those who can benefit from anti-tumor immunotherapy.

Keywords: COAD; immune; lncRNAs; overall survival; risk model.