Ly6c^hi Infiltrating Macrophages Promote Cyst Progression in Injured Conditional Ift88 Mice

Kidney360. 2021 Jun 24;2(6):989-995. doi: 10.34067/KID.0000882021.

Authors

Ernald Jules G Aloria¹, Cheng J Song¹, Zhang Li¹, Mandy J Croyle¹, Michal Mrug^{2

3}, Kurt A Zimmerman^{1

4}, Bradley K Yoder¹

Affiliations

¹ Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama.
² Department of Medicine, Division of Nephrology, University of Alabama at Birmingham, Birmingham, Alabama.
³ Department of Veterans Affairs Medical Center, Birmingham, Alabama.
⁴ Division of Nephrology, Department of Internal Medicine, The University of Oklahoma Health Science Center, Oklahoma City, Oklahoma.

Abstract

Ly6c^hi infiltrating macrophage numbers are increased in injured, conditional Ift88 mice, compared with controls.
Loss of Ly6c^hi infiltrating macrophages slows injury-accelerated cystic disease.
Ly6c^hi infiltrating macrophages drive cystic disease in non-Pkd1–deficient cystic models.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Cysts*
Macrophages*
Mice
Monocytes

Grants and funding