Efficacy of empiric esophageal dilation in patients with non-obstructive dysphagia: systematic review and meta-analysis

Scand J Gastroenterol. 2021 Dec;56(12):1490-1495. doi: 10.1080/00365521.2021.1971288. Epub 2021 Sep 3.

Abstract

Background and aims: Empiric esophageal dilation is frequently performed for non-obstructive dysphagia. Studies evaluating its efficacy have reported conflicting results. In this meta-analysis, we have evaluated the efficacy of esophageal dilation in the management of non-obstructive dysphagia.

Methods: We reviewed several databases from inception to 26 May 2021 to identify randomized controlled trials (RCTs) and observational studies that evaluated the role of empiric esophageal dilation for non-obstructive dysphagia. Our outcomes of interest were clinical success (improvement in dysphagia after dilation) and difference in post-operative dysphagia score between groups. For categorical variables, we calculated pooled odds ratios (OR) with 95% confidence intervals (CI); for continuous variables, we calculated standardized mean difference (SMD) with 95% CI. Data were analyzed using a random effects model. We used GRADE framework to ascertain the quality of evidence.

Results: We included 4 studies (3 RCTs and one observational) with 243 patients; there were 133 treated with empiric dilation and 110 controls. We found no significant difference in clinical success (OR (95% CI) 1.91 (0.89, 4.08)) or post-procedure dysphagia score between groups (SMD (95% CI) 0.38 (-0.37, 1.14)). Our findings remained consistent on subgroup analysis including RCTs only. Quality of evidence ranged from low to very low based on GRADE framework.

Conclusions: Our meta-analysis does not support the use of empiric esophageal dilation in patients with non-obstructive dysphagia. More studies are required to confirm these findings.

Keywords: Esophageal dilation; meta-analysis; non-obstructive dysphagia.

Publication types

  • Meta-Analysis
  • Systematic Review

MeSH terms

  • Deglutition Disorders* / etiology
  • Deglutition Disorders* / therapy
  • Dilatation
  • Endoscopy
  • Exercise Therapy
  • Humans