Epidemiologic and Genetic Associations of Erythropoietin With Blood Pressure, Hypertension, and Coronary Artery Disease

Hypertension. 2021 Nov;78(5):1555-1566. doi: 10.1161/HYPERTENSIONAHA.121.17597. Epub 2021 Sep 7.

Pengfei Sun^#¹, Nitin Kumar^#^{2

3}, Adrienne Tin^{4

5}, Jing Zhao¹, Michael R Brown⁶, Zesen Lin⁷, Min-Lee Yang^{2

3}, Qiwen Zheng⁸, Jia Jia¹, Lawrence F Bielak⁹, Bing Yu⁶, Eric Boerwinkle⁶, Kristina L Hunker^{2

3}, Josef Coresh⁴, Y Eugene Chen², Yong Huo¹, Sharon L R Kardia⁹, Rami Khoriaty¹⁰, Xiang Zhou¹¹, Alanna C Morrison⁶, Yan Zhang^{1

12}, Santhi K Ganesh^{2

3}

¹ Department of cardiology, Peking University First hospital, Beijing, China (P.S., J.Z., J.J., Y.H., Y.Z.).
² Division of Cardiovascular Medicine, Department of Internal Medicine (N.K., M.-L.Y., K.L.H., Y.E.C., S.K.G.), University of Michigan Medical School, Ann Arbor.
³ Department of Human Genetics (N.K., M.-L.Y., K.L.H., S.K.G.), University of Michigan Medical School, Ann Arbor.
⁴ Johns Hopkins Bloomberg School of Public Health, MD (A.T., J.C.).
⁵ University of Mississippi Medical Center (A.T.).
⁶ Human Genetics Center, Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston (M.R.B., B.Y., E.B., A.C.M.).
⁷ Department of Pharmacology (Z.L.), University of Michigan Medical School, Ann Arbor.
⁸ Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, China (Q.Z.).
⁹ Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor (L.F.B., S.L.R.K.).
¹⁰ Division of Hematology, Department of Internal Medicine and Department of Cell and Developmental Biology (R.K.), University of Michigan Medical School, Ann Arbor.
¹¹ Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor (X.Z.).
¹² Institute of Cardiovascular Disease, Peking University First Hospital, Beijing, China (Y.Z.).

^# Contributed equally.

Abstract

[Figure: see text].

Keywords: coronary artery disease; erythropoietin; hypertension; risk factors.