The effect of thyroid function on the risk of psychiatric readmission after hospitalization for major depressive disorder

Lu Yang; Xiaorui Yang; Tao Yang; Xiaohui Wu; Ping Sun; Yuncheng Zhu; Yousong Su; Wenjie Gu; Hong Qiu; Jianli Wang; Jun Chen; Yiru Fang

doi:10.1016/j.psychres.2021.114205

The effect of thyroid function on the risk of psychiatric readmission after hospitalization for major depressive disorder

Psychiatry Res. 2021 Nov:305:114205. doi: 10.1016/j.psychres.2021.114205. Epub 2021 Sep 6.

Authors

Lu Yang¹, Xiaorui Yang¹, Tao Yang¹, Xiaohui Wu¹, Ping Sun¹, Yuncheng Zhu¹, Yousong Su¹, Wenjie Gu¹, Hong Qiu¹, Jianli Wang², Jun Chen³, Yiru Fang⁴

Affiliations

¹ Clinical Research Center & Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
² School of Epidemiology and Public Health, Department of Psychiatry, Faculty of Medicine & Institute of Mental Health Research, University of Ottawa, Ontario K1N 6N5, Canada.
³ Clinical Research Center & Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai 200031, China; Shanghai Key Laboratory of Psychotic Disorders, Shanghai 201108, China; Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangzhou 510515, China. Electronic address: doctorcj2010@gmail.com.
⁴ Clinical Research Center & Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai 200031, China; Shanghai Key Laboratory of Psychotic Disorders, Shanghai 201108, China; Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangzhou 510515, China. Electronic address: yirufang@aliyun.com.

PMID: 34551381
DOI: 10.1016/j.psychres.2021.114205

Abstract

The relationship between thyroid function and depression has long been recognized, but little is known about the effect of thyroid function on the risk of readmission after hospitalization for major depressive disorder (MDD). This retrospective cohort study was aimed to explore the effect of thyroid function on psychiatric readmission after hospitalization for MDD. Data was derived from electronic medical records (EMR) of the Shanghai Mental Health Center (SMHC), Shanghai, China. Univariate and multivariate logistic regression analyses were conducted in subjects aged ≥ 18 years who had been hospitalized for MDD between January 1, 2007, and May 31, 2019. Of the 1803 eligible patients, 85 and 132 patients experienced psychiatric readmission within 90 days and 180 days after discharge respectively. Multivariate analyses showed that serum FT3 level (aOR=1.271; 95%CI=1.051-1.537) and comorbidity of thyroid disease (aOR=2,179; 95%CI=1.136-4.179) was independently associated with the risk of 90-day and 180-day readmission respectively. These findings indicated that high serum FT3 levels and comorbidity of thyroid disease could increase the risk of readmission after hospitalization for MDD. It is warranted to provide routine assessment and intervention of the thyroid function during the treatment of depression so as to prevent re-hospitalization.

Keywords: Major Depression; Real-world Studies; Rehospitalization; Retrospective Studies; Thyroid Hormones/*blood.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
China
Depressive Disorder, Major* / epidemiology
Depressive Disorder, Major* / therapy
Hospitalization
Humans
Patient Readmission
Retrospective Studies
Thyroid Gland