Complete ophthalmoplegia secondary to idiopathic intracranial hypertension managed successfully with dural sinus stenting: A case and systematic review

Clin Neurol Neurosurg. 2021 Oct:209:106910. doi: 10.1016/j.clineuro.2021.106910. Epub 2021 Aug 30.

Abstract

Idiopathic Intracranial Hypertension (IIH) typically occurs in obese (BMI >30 kg/m2) females of childbearing age in the absence of any apparent intracranial space-occupying lesion. Patients typically present with headache, nausea, vomiting, tinnitus, and blurry vision secondary to increased intracranial pressure, with more severe cases involving cranial neuropathies and ophthalmological manifestations. Complete ophthalmoplegia is a rare event in IIH. In such cases, aggressive management with pharmacological, endovascular, and surgical intervention is essential to hasten recovery and limit long-term neurological and visual deficits. Herein, we present a rare case of a patient with IIH associated with third, fourth, and sixth cranial nerve palsies, resulting in complete unilateral ophthalmoplegia, who underwent dural sinus stenting and 2.5-year follow-up revealed complete resolution with full extraocular movements. We also perform a systematic literature review of complete and partial ophthalmoplegia secondary to IIH, highlighting the associated presentations, pathophysiology, management, and outcomes.

Keywords: Dural Sinus Stenting; Dural Venogram; Fourth Nerve Palsy; Idiopathic Intracranial Hypertension; Ophthalmoplegia; Pseudotumor Cerebri; Third Nerve Palsy.

Publication types

  • Case Reports
  • Review
  • Systematic Review

MeSH terms

  • Adult
  • Cranial Sinuses / surgery*
  • Female
  • Humans
  • Ophthalmoplegia / etiology
  • Ophthalmoplegia / surgery*
  • Pseudotumor Cerebri / complications
  • Pseudotumor Cerebri / surgery*
  • Stents*
  • Treatment Outcome