Successful Treatment with Crushed Sofosbuvir/Velpatasvir of a Patient with Decompensated Cirrhosis C and Thrombocytopenia

Aiko Murayama; Kazuto Tajiri; Chiharu Kanegane; Jun Murakami; Yuka Hayashi; Ichiro Yasuda

doi:10.1159/000518306

Successful Treatment with Crushed Sofosbuvir/Velpatasvir of a Patient with Decompensated Cirrhosis C and Thrombocytopenia

Case Rep Gastroenterol. 2021 Aug 6;15(2):729-735. doi: 10.1159/000518306. eCollection 2021 May-Aug.

Authors

Aiko Murayama¹, Kazuto Tajiri¹, Chiharu Kanegane², Jun Murakami³, Yuka Hayashi¹, Ichiro Yasuda¹

Affiliations

¹ The Third Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan.
² Department of Pediatrics, National Hospital Organization Toyama Hospital, Toyama, Japan.
³ Division of Transfusion Medicine and Cell Therapy, Toyama University Hospital, Toyama, Japan.

Abstract

A 36-year-old woman with decompensated liver cirrhosis type C was referred to our hospital to receive antiviral treatment for hepatitis C virus (HCV). She had been diagnosed with intractable epilepsy and cerebral palsy at birth and was managed by central venous nutrition and nasal gastric feeding. At age 34 years, she was diagnosed with thrombocytopenia, probably associated with HCV infection. She showed refractory ascites for several months and was therefore administered crushed sofosbuvir/velpatasvir tablets via a nasal gastric tube. Her HCV infection was successfully eradicated, her ascites disappeared, and thrombocytopenia improved with a marked decrease in platelet-associated IgG.

Keywords: Crushed administration; Decompensated cirrhosis C; Direct-acting antiviral; Intractable epilepsy; Thrombocytopenia.

Publication types

Case Reports