Availability and use of fetal fibronectin testing and transvaginal ultrasound for preterm labor evaluation in the United States

J Matern Fetal Neonatal Med. 2022 Dec;35(25):8586-8593. doi: 10.1080/14767058.2021.1989403. Epub 2021 Oct 14.

Abstract

Objective: Measure availability and use of fetal fibronectin (fFN) testing and transvaginal ultrasound to measure cervical length (TVCL) for symptomatic preterm labor (PTL) patients. Additionally, assess the presence and impact of PTL triage protocols.

Study design: Cross-sectional online survey among clinicians from 255 unique hospitals regarding prior 12-month practices (pre-COVID-19).

Results: fFN testing was always available in 87% (221) of hospitals, while TVCL was always available in 69% (175) of hospitals. Utilization was lower: fFN specimens were often/always collected in 61% (156) of hospitals and TVCL was often/always performed in 43% (110) of hospitals. fFN testing was significantly more likely than TVCL to be available and used (p < .05). Written PTL protocols were available in 47% (121) of hospitals but not consistently followed.

Conclusion: The most accurate risk assessment approach for imminent spontaneous preterm birth is the implementation of a universal screening program for symptomatic patients, including fFN testing and TVCL.

Keywords: Fetal fibronectin testing (fFN); guidelines; preterm labor (PTL); spontaneous preterm birth (sPTB); transvaginal ultrasound to measure cervical length (TVCL).

MeSH terms

  • COVID-19*
  • Cervical Length Measurement / methods
  • Cervix Uteri / diagnostic imaging
  • Cross-Sectional Studies
  • Female
  • Fibronectins
  • Humans
  • Infant, Newborn
  • Obstetric Labor, Premature* / diagnostic imaging
  • Predictive Value of Tests
  • Pregnancy
  • Premature Birth* / diagnosis
  • United States

Substances

  • Fibronectins