Maximizing detection and optimal characterization of local abnormal ventricular activity in nonischemic cardiomyopathy: LAVAMAX & LAVAFLOW

Karl Magtibay; Stéphane Massé; Ahmed Niri; Robert D Anderson; Ram B Kumar; D Curtis Deno; Kumaraswamy Nanthakumar

doi:10.1016/j.hroo.2021.08.006

Maximizing detection and optimal characterization of local abnormal ventricular activity in nonischemic cardiomyopathy: LAVA_MAX & LAVA_FLOW

Heart Rhythm O2. 2021 Sep 4;2(5):529-536. doi: 10.1016/j.hroo.2021.08.006. eCollection 2021 Oct.

Authors

Karl Magtibay¹, Stéphane Massé¹, Ahmed Niri¹, Robert D Anderson¹, Ram B Kumar², D Curtis Deno², Kumaraswamy Nanthakumar¹

Affiliations

¹ The Hull Family Cardiac Fibrillation Management Laboratory, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, Toronto, Canada.
² Abbott Laboratories, St. Paul, Minnesota.

Abstract

Background: Sites of local abnormal ventricular activation (LAVA) are ventricular tachycardia (VT) ablation targets. In nonischemic cardiomyopathy (NICM), minute and sparse LAVA potentials are mapped with difficulty with direction-sensitive bipolar electrograms (EGM). A method for its optimal characterization independent of electrode orientation has not been explored.

Objective: Maximize voltages and calculate overall activation direction at LAVA sites, independent of catheter and wave direction, using omnipolar technology (OT) in NICM.

Methods: Four diseased isolated human hearts from NICM patients were mapped epicardially using a high-density grid. Bipolar EGMs with at least 2 activation segments separated by at least 25 ms were identified. We used OT to maximize voltages (LAVA_MAX) and measured overall wave direction (LAVA_FLOW) for both segments. Clinically relevant voltage proportion (CRVP) was used to estimate the proportion of directionally corrected bipoles. Concordance and changes in direction vectors were measured via mean vector length and angular change.

Results: OT provides maximal LAVA voltages (OT: 0.83 ± 0.09 mV vs Bi: 0.61 ± 0.06 mV, P < .05) compared to bipolar EGMs. OT optimizes LAVA voltages, with 32% (CRVP) of LAVA bipoles directionally corrected by OT. OT direction vectors at LAVA sites demonstrate general concordance, with an average of 62% ± 5%. A total of 72% of direction vectors change by more than 35° at LAVA sites.

Conclusion: The omnipolar mapping approach allows maximizing voltage and determining the overall direction of wavefront activity at LAVA sites in NICM.

Keywords: Ablation; LAVA; Mapping; Omnipolar; Ventricular tachycardia.