The adaptive aging brain

Liviu Aron; Joseph Zullo; Bruce A Yankner

doi:10.1016/j.conb.2021.09.009

The adaptive aging brain

Curr Opin Neurobiol. 2022 Feb:72:91-100. doi: 10.1016/j.conb.2021.09.009. Epub 2021 Oct 22.

Authors

Liviu Aron¹, Joseph Zullo¹, Bruce A Yankner²

Affiliations

¹ Department of Genetics, Harvard Medical School, Boston, 02115, MA, USA.
² Department of Genetics, Harvard Medical School, Boston, 02115, MA, USA. Electronic address: bruce_yankner@hms.harvard.edu.

Abstract

The aging brain is shaped by many structural and functional alterations. Recent cross-disciplinary efforts have uncovered powerful and integrated adaptive mechanisms that promote brain health and prevent functional decline during aging. Here, we review some of the most robust adaptive mechanisms and how they can be engaged to protect, and restore the aging brain.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Aging
Brain* / physiology
Humans

Abstract

Publication types

MeSH terms

Grants and funding