Angiokeratoma-like purpuric palmar nodules following chemotherapy

Dermatol Online J. 2021 Aug 15;27(8). doi: 10.5070/D327854702.

Abstract

We describe a patient with leukemia undergoing chemotherapy who developed painful purpuric nodules of the digits. These findings were concerning for endocarditis (clinically) and angiokeratomas on gross histology. After extensive evaluation, we report the development of painful purpuric nodules as a likely side effect of the patient's therapeutic regimen (hydroxyurea, danorubicin, cytarabine, and methotrexate).

Publication types

  • Case Reports

MeSH terms

  • Angiokeratoma / chemically induced*
  • Angiokeratoma / diagnosis
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects*
  • Cytarabine / administration & dosage
  • Daunorubicin / administration & dosage
  • Diagnosis, Differential
  • Female
  • Hand Dermatoses / chemically induced*
  • Hand Dermatoses / diagnosis
  • Humans
  • Hydroxyurea / administration & dosage
  • Leukemia / drug therapy*
  • Methotrexate / administration & dosage
  • Middle Aged
  • Purpura / chemically induced*
  • Purpura / diagnosis
  • Purpura / pathology
  • Skin Neoplasms / chemically induced*
  • Skin Neoplasms / diagnosis

Substances

  • Cytarabine
  • Hydroxyurea
  • Methotrexate
  • Daunorubicin