'Moderate global aphasia': A generalized decline of language processing caused by glioma surgery but not stroke

Andrey Zyryanov; Ekaterina Stupina; Elizaveta Gordeyeva; Olga Buivolova; Evdokiia Novozhilova; Yulia Akinina; Oleg Bronov; Natalia Gronskaya; Galina Gunenko; Ekaterina Iskra; Elena Ivanova; Anton Kalinovskiy; Evgenii Kliuev; Dmitry Kopachev; Elena Kremneva; Oksana Kryuchkova; Igor Medyanik; Nikita Pedyash; Viktoria Pozdniakova; Igor Pronin; Kristina Rainich; Andrey Reutov; Anastasia Samoukina; Anastasia Shlyakhova; Andrey Sitnikov; Olga Soloukhina; Konstantin Yashin; Valeriya Zelenkova; Andrey Zuev; Maria V Ivanova; Olga Dragoy

doi:10.1016/j.bandl.2021.105057

'Moderate global aphasia': A generalized decline of language processing caused by glioma surgery but not stroke

Brain Lang. 2022 Jan:224:105057. doi: 10.1016/j.bandl.2021.105057. Epub 2021 Dec 6.

Authors

Andrey Zyryanov¹, Ekaterina Stupina², Elizaveta Gordeyeva², Olga Buivolova³, Evdokiia Novozhilova², Yulia Akinina², Oleg Bronov⁴, Natalia Gronskaya⁵, Galina Gunenko⁶, Ekaterina Iskra⁷, Elena Ivanova⁸, Anton Kalinovskiy⁶, Evgenii Kliuev⁹, Dmitry Kopachev¹⁰, Elena Kremneva¹⁰, Oksana Kryuchkova¹¹, Igor Medyanik¹², Nikita Pedyash¹³, Viktoria Pozdniakova², Igor Pronin¹⁴, Kristina Rainich², Andrey Reutov¹⁵, Anastasia Samoukina², Anastasia Shlyakhova², Andrey Sitnikov¹⁶, Olga Soloukhina², Konstantin Yashin¹², Valeriya Zelenkova², Andrey Zuev¹³, Maria V Ivanova¹⁷, Olga Dragoy¹⁸

Affiliations

¹ Center for Language and Brain, HSE University, 3 Krivokolenny Pereulok, Moscow 101000, Russia. Electronic address: aszyryanov@hse.ru.
² Center for Language and Brain, HSE University, 3 Krivokolenny Pereulok, Moscow 101000, Russia.
³ Center for Language and Brain, HSE University, 3 Krivokolenny Pereulok, Moscow 101000, Russia; Federal Center for Brain and Neurotechnologies, 1 Building 10 Ostrovityanova Ulitsa, Moscow 117997, Russia.
⁴ Department of Radiology, National Medical and Surgical Center Named after N.I. Pirogov, 70 Nizhnyaya Pervomayskaya Ulitsa, Moscow 105203, Russia.
⁵ Center for Language and Brain, HSE University, 25/12 Bolshaya Pecherskaya Ulitsa, Nizhny Novgorod 603155, Russia.
⁶ Department of Neurooncology, Federal Center of Neurosurgery Novosibirsk, 132/1 Nemirovicha-Danchenko Ulitsa, Novosibirsk 630048, Russia.
⁷ Center for Language and Brain, HSE University, 3 Krivokolenny Pereulok, Moscow 101000, Russia; Center for Speech Pathology and Neurorehabilitation, 20/1 Nikoloyamskaya Ulitsa, Moscow 109240, Russia.
⁸ Federal Center for Brain and Neurotechnologies, 1 Building 10 Ostrovityanova Ulitsa, Moscow 117997, Russia; Pirogov Russian National Research Medical University, 1 Ostrovityanova Ulitsa, Moscow 117198, Russia.
⁹ Department of Radiology, Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod 603005, Russia.
¹⁰ Research Center of Neurology, 80 Volokolamskoye Shosse, Moscow 125367, Russia.
¹¹ Department of Radiology, Central Clinical Hospital with Outpatient Health Center of the Business Administration for the President of the Russian Federation, 15 Marshala Timoshenko Ulitsa, Moscow 121359, Russia.
¹² Department of Neurosurgery, Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod 603005, Russia.
¹³ Department of Neurosurgery, National Medical and Surgical Center named after N.I. Pirogov, 70 Nizhnyaya Pervomayskaya Ulitsa, Moscow 105203, Russia.
¹⁴ Department of Neuroradiology, National Medical Research Center for Neurosurgery named after N. N. Burdenko, 16 4-ya Tverskaya-Yamskaya Ulitsa, Moscow 125047, Russia.
¹⁵ Department of Neurosurgery, Central Clinical Hospital with Outpatient Health Center of the Business Administration for the President of the Russian Federation, 15 Marshala Timoshenko Ulitsa, Moscow 121359, Russia.
¹⁶ Department of Neurosurgery, Federal Centre of Treatment and Rehabilitation of the Ministry of Healthcare of the Russian Federation, 3 Ivan'kovskoye Shosse, Moscow 125367, Russia.
¹⁷ Aphasia Recovery Lab, Department of Psychology, University of California, Berkley, 210 Barker Hall, CA 94720, USA.
¹⁸ Center for Language and Brain, HSE University, 3 Krivokolenny Pereulok, Moscow 101000, Russia; Institute of Linguistics, Russian Academy of Sciences, 1 bld. 1 Bolshoy Kislovsky lane, Moscow 125009, Russia.

Abstract

Unlike stroke, neurosurgical removal of left-hemisphere gliomas acts upon a reorganized language network and involves brain areas rarely damaged by stroke. We addressed whether this causes the profiles of neurosurgery- and stroke-induced language impairments to be distinct. K-means clustering of language assessment data (neurosurgery cohort: N = 88, stroke cohort: N = 95) identified similar profiles in both cohorts. But critically, a cluster of individuals with specific phonological deficits was only evident in the stroke but not in the neurosurgery cohort. Thus, phonological deficits are less clearly distinguished from other language deficits after glioma surgery compared to stroke. Furthermore, the correlations between language production and comprehension scores at different linguistic levels were more extensive in the neurosurgery than in the stroke cohort. Our findings suggest that neurosurgery-induced language impairments do not correspond to those caused by stroke, but rather manifest as a 'moderate global aphasia' - a generalized decline of language processing abilities.

Keywords: Aphasia; Glioma; K-means clustering; Neurosurgery; Stroke.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Aphasia* / etiology
Comprehension
Glioma* / complications
Glioma* / surgery
Humans
Language
Language Disorders* / complications
Language Disorders* / etiology
Magnetic Resonance Imaging
Stroke* / complications

Grants and funding

R01 DC016345/DC/NIDCD NIH HHS/United States