Psoriasis Severity, Comorbidities, and Treatment Response Differ among Geographic Regions in the United States

Clinton W Enos; Katie A O'Connell; Ryan W Harrison; Robert R McLean; Blessing Dube; Abby S Van Voorhees

doi:10.1016/j.xjidi.2021.100025

Psoriasis Severity, Comorbidities, and Treatment Response Differ among Geographic Regions in the United States

JID Innov. 2021 May 6;1(2):100025. doi: 10.1016/j.xjidi.2021.100025. eCollection 2021 Jun.

Authors

Clinton W Enos¹, Katie A O'Connell¹, Ryan W Harrison², Robert R McLean², Blessing Dube², Abby S Van Voorhees¹

Affiliations

¹ Department of Dermatology, Eastern Virginia Medical School, Norfolk, Virginia, USA.
² CorEvitas, LLC, Waltham, Massachusetts, USA.

Abstract

Little is known about how psoriatic disease characteristics and treatment outcomes differ geographically in the United States. Our aim was to explore real-world, geographic variations in the use of biologic classes and outcomes within the Corrona Psoriasis Registry. Patient demographics and disease characteristics were assessed at biologic initiation and at 6 months. Logistic regressions were conducted to evaluate the odds of achieving targeted outcomes for seven United States geographic regions. We examined 737 biologic initiations among 717 patients. IL-17 inhibitors were used most frequently (45%), followed by IL-12‒IL-23 and IL-23 inhibitors (38%) and TNF inhibitors (17%). The proportions of patients with obesity (body mass index > 30) and very severe psoriasis (body surface area > 20) were greatest in the East South Central and West South Central regions. After adjusting for age, sex, race, body mass index, and baseline body surface area, decreased odds of achieving 75% improvement in PASI at 6 months were observed among patients in the East South Central (OR = 0.47, 95% confidence interval = 0.28-0.79, P = 0.004), West South Central (OR = 0.43, 95% confidence interval = 0.22-0.87, P = 0.019), and Pacific (OR = 0.49, 95% confidence interval = 0.28-0.84, P = 0.010) regions compared with those observed among patients in the Northeast. The East South Central and West South Central regions may have the greatest frequencies of very severe disease burden and, along with the Pacific region, may be less likely to achieve targeted response within 6 months of initiating biologic therapy.

Keywords: BMI, body mass index; BSA, body surface area; CI, confidence interval; E South Cent, East South Central; IGA, Investigator’s Global Assessment; IL-12/23i, IL-12‒IL-23 inhibitor; IL-17i, IL-17 inhibitor; IL-23i, IL-23 inhibitor; PASI 75, 75% improvement in PASI; TNFi, TNF inhibitor; US, United States; W South Cent, West South Central.