For the last two years, the medical world has been focused on the COVID-19 pandemic. Most health organizations throughout the world agree that this pandemic will disappear or become less virulent in the coming years, like most viral infectious diseases. While the focus of the medical authorities in Israel changed in the last two years, cancer diseases remained the leading cause of death in Israel. Nevertheless, the percentage of cancer survivors is rising slowly in the Western world, as well as in Israel. Some of these wonderful achievements are related to new technologies in cancer diagnosis and treatment, together with completely new treatment strategies based on innovative medications that entered the treatment of oncology in the last decade. In this edition of "Harefuah", dedicated to oncology, we will present some examples of the new paradigms in the treatment of cancer diseases, described in research articles, case reports and reviews.