Synthesis of aromatic lactone analogues of Lipoxin A4

Aya Ismael; Muhammad Zeeshan; Jørn H Hansen

doi:10.1186/s13104-022-05917-4

Synthesis of aromatic lactone analogues of Lipoxin A4

BMC Res Notes. 2022 Feb 9;15(1):30. doi: 10.1186/s13104-022-05917-4.

Authors

Aya Ismael^#¹, Muhammad Zeeshan^#¹, Jørn H Hansen²

Affiliations

¹ Department of Chemistry, Chemical Synthesis and Analysis Division, UiT The Arctic University of Norway, 9037, Tromsø, Norway.
² Department of Chemistry, Chemical Synthesis and Analysis Division, UiT The Arctic University of Norway, 9037, Tromsø, Norway. jorn.h.hansen@uit.no.

^# Contributed equally.

Abstract

Objective: Synthesis of novel aromatic Lipoxin A4 lactone analogues.

Results: Novel para-substituted aromatic lactone analogues of Lipoxin A4 have been synthesized in a convergent manner with six steps in the longest linear sequence in 12-13% yields, employing 2-deoxy-D-ribose as a chiral pool starting material and the classical E-selective Wittig olefination.

Keywords: Aromatics; Lactones; Lipoxin analogues; Wittig olefination.

MeSH terms

Lactones*
Lipoxins*

Substances

Lactones
Lipoxins
lipoxin A4