Closing the gap: Tricellulin/α-catenin interaction maintains epithelial integrity at vertices

J Cell Biol. 2022 Apr 4;221(4):e202202009. doi: 10.1083/jcb.202202009. Epub 2022 Feb 22.

Abstract

Tricellular junctions play a critical role in regulating epithelial barrier function. In this issue, Cho et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202009037) demonstrate a novel interaction between tricellulin and α-catenin, which connects tricellular junctions to the actomyosin cytoskeleton, thus supporting the epithelial barrier at cell vertices.

Publication types

  • Editorial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Actin Cytoskeleton
  • Actomyosin
  • MARVEL Domain Containing 2 Protein*
  • Tight Junctions*
  • alpha Catenin / genetics

Substances

  • MARVEL Domain Containing 2 Protein
  • alpha Catenin
  • Actomyosin