Temporary vessel occlusion in cerebral aneurysm surgery guided by direct cortical motor evoked potentials

Abstract

Background: Temporary clipping is an important tool in the vascular neurosurgeon's armamentarium. We routinely utilize intraoperative neurophysiological monitoring (IONM) for complex brain aneurysm surgery cases, relying on direct cortical motor evoked potential (DCMEP) alerts to guide the duration of temporary clipping. Previous studies have argued for relatively short and intermittent temporary clipping strategies. In this study, we sought to assess the maximal permissive temporary clipping time during complex aneurysm surgery. To do this, we assessed patient outcome in relation to temporary clip duration guided by DCMEP.

Methods: We queried our prospectively collected neuromonitoring database for anterior circulation aneurysm cases where temporary clipping was utilized by a single cerebrovascular surgeon between 2018 and 2021. Operative and IONM reports were reviewed. Patients in whom the duration of temporary clipping could not be determined were excluded. The operative strategy permissively allowed continuous temporary clipping as long as no neuromonitoring alerts were encountered. Maximal permissive parent artery occlusion time (Clip_max) was recorded as the longest duration of tolerated temporary vessel clipping without decrement in DCMEP.

Results: A total of 41 complex anterior circulation aneurysm clipping cases met criteria for this study. The mean Clip_max for all cases was just over 19 min and did not differ between ruptured and unruptured aneurysms. Initial alert times were not found to be predictive of final permissive temporary clip duration after re-perfusion. In 100% (41/41) of cases, the aneurysm was completely clip occluded without residual on catheter angiogram. Stable or improved modified Rankin Score was achieved in 98% (40/41) of cases at 3-month follow-up.

Conclusions: This study demonstrates that using DCMEP can facilitate relatively long but safe temporary clipping durations in complex anterior circulation aneurysm surgery. In the endovascular era with only a limited subset of technically challenging aneurysms needing open surgical treatment, extended permissive temporary clipping guided by DCMEPs can significantly enhance a surgeon's ability to achieve excellent technical and clinical outcomes.

Keywords: Cerebral aneurysm; Direct cortical motor evoked potentials; Intraoperative neurophysiological monitoring; Motor evoked potentials; Neurosurgery.