A patient with Parkinson's disease (PD) who was examined as a candidate for DBS was initially rejected due to extensive brain calcifications. Upon second opinion and planning of trajectories she underwent successful surgery. Genetic analyses identified a mutation in SLC20A2, a gene known to cause brain calcifications, but no mutation known to cause PD was found.
Keywords: Brain calcifications; Deep brain stimulation; Early-onset Parkinson's disease; Genetics of Parkinson's disease; SLC20A2.
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