Mathematical modelling of oxygenation under veno-venous ECMO configuration using either a femoral or a bicaval drainage

Jonathan Charbit; Elie Courvalin; Geoffrey Dagod; Pauline Deras; Thomas Laumon; Mehdi Girard; Camille Maury; Hugues Weber; Xavier Capdevila

doi:10.1186/s40635-022-00434-x

Mathematical modelling of oxygenation under veno-venous ECMO configuration using either a femoral or a bicaval drainage

Intensive Care Med Exp. 2022 Mar 28;10(1):10. doi: 10.1186/s40635-022-00434-x.

Authors

Jonathan Charbit^{1

2}, Elie Courvalin³, Geoffrey Dagod³, Pauline Deras³, Thomas Laumon³, Mehdi Girard³, Camille Maury³, Hugues Weber³, Xavier Capdevila³

Affiliations

¹ Département d'Anesthésie Réanimation Lapeyronie, Hôpital Lapeyronie, 371 Avenue du Doyen G. Giraud, 34295, Montpellier, France. j-charbit@chu-montpellier.fr.
² Critical Care Unit, Lapeyronie University Hospital, 34295, Montpellier Cedex 5, France. j-charbit@chu-montpellier.fr.
³ Département d'Anesthésie Réanimation Lapeyronie, Hôpital Lapeyronie, 371 Avenue du Doyen G. Giraud, 34295, Montpellier, France.

Abstract

Background: The bicaval drainage under veno-venous extracorporeal membrane oxygenation (VV ECMO) was compared in present experimental study to the inferior caval drainage in terms of systemic oxygenation.

Method: Two mathematical models were built to simulate the inferior vena cava-to-right atrium (IVC → RA) route and the bicaval drainage-to-right atrium return (IVC + SVC → RA) route using the following parameters: cardiac output (Q_C), IVC flow/Q_C ratio, venous oxygen saturation, extracorporeal pump flow (Q_EC), and pulmonary shunt (PULM-Shunt) to obtain pulmonary artery oxygen saturation (S_PAO₂) and systemic blood oxygen saturation (SaO₂).

Results: With the IVC → RA route, S_PAO₂ and SaO₂ increased linearly with Q_EC/Q_C until the threshold of the IVC flow/Q_C ratio, beyond which the increase in S_PAO₂ reached a plateau. With the IVC + SVC → RA route, S_PAO₂ and SaO₂ increased linearly with Q_EC/Q_C until 100% with Q_EC/Q_C = 1. The difference in required Q_EC/Q_C between the two routes was all the higher as SaO₂ target or PULM-Shunt were high, and occurred all the earlier as PULM-Shunt were high. The required Q_EC between the two routes could differ from 1.0 L/min (Q_C = 5 L/min) to 1.5 L/min (Q_C = 8 L/min) for SaO₂ target = 90%. Corresponding differences of Q_EC for SaO₂ target = 94% were 4.7 L/min and 7.9 L/min, respectively.

Conclusion: Bicaval drainage under ECMO via the IVC + SVC → RA route gave a superior systemic oxygenation performance when both Q_EC/Q_C and pulmonary shunt were high. The VV-V ECMO configuration (IVC + SVC → RA route) might be an attractive rescue strategy in case of refractory hypoxaemia under VV ECMO.

Keywords: Bicaval drainage; Oxygenation determinants; Oxygenation performance; Pulmonary shunt; Rescue therapy; Structural recirculation; Superior cava drainage; Superior cava shunt; Triple cannulation; VV-V configuration.