O-Linked β- N-Acetylglucosamine Modification: Linking Hypertension and the Immune System

Rinaldo Rodrigues Dos Passos Junior; Gisele Facholi Bomfim; Fernanda R Giachini; Rita C Tostes; Victor Vitorino Lima

doi:10.3389/fimmu.2022.852115

O-Linked β- N-Acetylglucosamine Modification: Linking Hypertension and the Immune System

Front Immunol. 2022 Mar 17:13:852115. doi: 10.3389/fimmu.2022.852115. eCollection 2022.

Authors

Rinaldo Rodrigues Dos Passos Junior^{1

2}, Gisele Facholi Bomfim³, Fernanda R Giachini^{1

2}, Rita C Tostes⁴, Victor Vitorino Lima¹

Affiliations

¹ Institute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garças, Brazil.
² Institute of Biological Sciences, Federal University of Goias, Goiânia, Brazil.
³ Institute of Health Sciences, Federal University of Mato Grosso, Sinop, Brazil.
⁴ Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

Abstract

The O-linked β-N-acetylglucosamine modification (O-GlcNAcylation) of proteins dynamically regulates protein function, localization, stability, and interactions. This post-translational modification is intimately linked to cardiovascular disease, including hypertension. An increasing number of studies suggest that components of innate and adaptive immunity, active players in the pathophysiology of hypertension, are targets for O-GlcNAcylation. In this review, we highlight the potential roles of O-GlcNAcylation in the immune system and discuss how those immune targets of O-GlcNAcylation may contribute to arterial hypertension.

Keywords: O-glcnacylation modification; adaptive immunity (ADIM); hypertension; immune system (IS); innate immunity (basic sciences).

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Acetylglucosamine*
Humans
Hypertension*
Immune System / metabolism
Protein Processing, Post-Translational
Proteins / metabolism

Substances

Proteins
Acetylglucosamine