Response under pressure: deploying emerging technologies to understand B-cell-mediated immunity in COVID-19

Matthew C Woodruff; Doan C Nguyen; Caterina E Faliti; Ankur Singh Saini; F Eun-Hyung Lee; Ignacio Sanz

doi:10.1038/s41592-022-01450-1

Response under pressure: deploying emerging technologies to understand B-cell-mediated immunity in COVID-19

Nat Methods. 2022 Apr;19(4):387-391. doi: 10.1038/s41592-022-01450-1.

Authors

Matthew C Woodruff^{1

2}, Doan C Nguyen³, Caterina E Faliti^{1

2}, Ankur Singh Saini^{1

2}, F Eun-Hyung Lee³, Ignacio Sanz^{4

5}

Affiliations

¹ Department of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA.
² Emory Autoimmunity Center of Excellence, Emory University, Atlanta, GA, USA.
³ Department of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University, Atlanta, GA, USA.
⁴ Department of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA. Ignacio.sanz@emory.edu.
⁵ Emory Autoimmunity Center of Excellence, Emory University, Atlanta, GA, USA. Ignacio.sanz@emory.edu.

Abstract

Critical technological advances have enabled the rapid investigations into the immune responses elicited by SARS-CoV-2, the pathogen responsible for the COVID-19 pandemic. In this Comment, we discuss the cutting-edge methods used to deconvolute the B cell responses against this virus, and the significant impact they have had in the ongoing public health crisis.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adaptive Immunity
COVID-19*
Humans
Immunity, Cellular
SARS-CoV-2

Abstract

Publication types

MeSH terms

Grants and funding