Association of lifetime major depressive disorder with enhanced attentional sensitivity measured with P3 response in young adult twins

Sini M Koskinen; Jyrki Ahveninen; Teija Kujala; Jaakko Kaprio; Brian F O'Donnell; Daria Osipova; Richard J Viken; Risto Näätänen; Richard J Rose

doi:10.1016/j.biopsycho.2022.108345

Association of lifetime major depressive disorder with enhanced attentional sensitivity measured with P3 response in young adult twins

Biol Psychol. 2022 May:171:108345. doi: 10.1016/j.biopsycho.2022.108345. Epub 2022 May 5.

Authors

Sini M Koskinen¹, Jyrki Ahveninen², Teija Kujala³, Jaakko Kaprio⁴, Brian F O'Donnell⁵, Daria Osipova⁶, Richard J Viken⁷, Risto Näätänen⁸, Richard J Rose⁹

Affiliations

¹ Cognitive Brain Research Unit, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, POB 21, FI-00014 Helsinki, Finland. Electronic address: sini.koskinen@helsinki.fi.
² Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, Charlestown, MA 02129, USA; Department of Radiology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA. Electronic address: jahveninen@mgh.harvard.edu.
³ Cognitive Brain Research Unit, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, POB 21, FI-00014 Helsinki, Finland. Electronic address: teija.m.kujala@helsinki.fi.
⁴ Department of Public Health & Institute for Molecular Medicine, University of Helsinki, POB 4, FI-00014 Helsinki, Finland. Electronic address: jaakko.kaprio@helsinki.fi.
⁵ Department of Psychological & Brain Sciences, Indiana University, 1101 E 10th St, Bloomington, IN 47405, USA. Electronic address: bodonnel@indiana.edu.
⁶ Cognitive Brain Research Unit, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, POB 21, FI-00014 Helsinki, Finland. Electronic address: dariaosipova@gmail.com.
⁷ Department of Psychological & Brain Sciences, Indiana University, 1101 E 10th St, Bloomington, IN 47405, USA. Electronic address: viken@indiana.edu.
⁸ Cognitive Brain Research Unit, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, POB 21, FI-00014 Helsinki, Finland. Electronic address: risto.naatanen@helsinki.fi.
⁹ Department of Psychological & Brain Sciences, Indiana University, 1101 E 10th St, Bloomington, IN 47405, USA. Electronic address: rose@indiana.edu.

Abstract

Major depression is associated with alterations in the auditory P3 event-related potential (ERP). However, the persistence of these abnormalities after recovery from depressive episodes, especially in young adults, is not well known. Furthermore, the potential influence of substance use on this association is poorly understood. Young adult twin pairs (N = 177) from the longitudinal FinnTwin16 study were studied with a psychiatric interview, and P3a and P3b ERPs elicited by task-irrelevant novel sounds and targets, respectively. Dyadic linear mixed-effect models were used to distinguish the effects of lifetime major depressive disorder from familial factors and effects of alcohol problem drinking and tobacco smoking. P3a amplitude was significantly increased and P3b latency decreased, in individuals with a history of lifetime major depression, when controlling the fixed effects of alcohol abuse, tobacco, gender, twins' birth order, and zygosity. These results suggest that past lifetime major depressive disorder may be associated with enhanced attentional sensitivity.

Keywords: Event-Related Potentials; Major Depressive Disorder; P3; Twin Study; Young Adults.

Publication types

Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Alcoholism*
Attention / physiology
Depressive Disorder, Major*
Event-Related Potentials, P300 / physiology
Evoked Potentials
Humans
Young Adult

Abstract

Publication types

MeSH terms

Grants and funding