The use of ECMO in pediatric granulomatosis with polyangiitis

Pediatr Rheumatol Online J. 2022 May 10;20(1):35. doi: 10.1186/s12969-022-00693-8.

Abstract

Background: Granulomatosis with polyangiitis (GPA) vasculitis with pulmonary-renal syndrome rarely presents in children and is associated with high mortality rates.

Case presentation: We present the case of a 13-year-old male with newly diagnosed GPA vasculitis, treated with extracorporeal membrane oxygenation, continuous renal replacement therapy, plasmapheresis, rituximab, cyclophosphamide, and corticosteroids.

Conclusion: This case presentation demonstrates that ECMO can be used as a life supporting therapy in pediatric patients with pulmonary hemorrhage from ANCA vasculitis in conjunction with other therapies.

Keywords: AAV; ANCA; ECMO; HD; Vasculitis.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis* / complications
  • Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis* / therapy
  • Antibodies, Antineutrophil Cytoplasmic
  • Child
  • Cyclophosphamide / therapeutic use
  • Extracorporeal Membrane Oxygenation*
  • Granulomatosis with Polyangiitis* / complications
  • Granulomatosis with Polyangiitis* / therapy
  • Humans
  • Lung Diseases*
  • Male
  • Rituximab / therapeutic use

Substances

  • Antibodies, Antineutrophil Cytoplasmic
  • Rituximab
  • Cyclophosphamide