Kidney Paired Donation Chains Initiated by Deceased Donors

Wen Wang; Alan B Leichtman; Michael A Rees; Peter X-K Song; Valarie B Ashby; Tempie Shearon; John D Kalbfleisch

doi:10.1016/j.ekir.2022.03.023

Kidney Paired Donation Chains Initiated by Deceased Donors

Kidney Int Rep. 2022 Mar 28;7(6):1278-1288. doi: 10.1016/j.ekir.2022.03.023. eCollection 2022 Jun.

Authors

Wen Wang^{1

2}, Alan B Leichtman^{2

3}, Michael A Rees⁴, Peter X-K Song^{1

2}, Valarie B Ashby^{1

2}, Tempie Shearon^{1

2}, John D Kalbfleisch^{1

2}

Affiliations

¹ Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.
² Kidney Epidemiology and Cost Center, University of Michigan, Ann Arbor, Michigan, USA.
³ Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA.
⁴ Department of Urology, University of Toledo Medical Center, Toledo, Ohio, USA.

Abstract

Introduction: Rather than generating 1 transplant by directly donating to a candidate on the waitlist, deceased donors (DDs) could achieve additional transplants by donating to a candidate in a kidney paired donation (KPD) pool, thereby, initiating a chain that ends with a living donor (LD) donating to a candidate on the waitlist. We model outcomes arising from various strategies that allow DDs to initiate KPD chains.

Methods: We base simulations on actual 2016 to 2017 US DD and waitlist data and use simulated KPD pools to model DD-initiated KPD chains. We also consider methods to assess and overcome the primary criticism of this approach, namely the potential to disadvantage blood type O-waitlisted candidates.

Results: Compared with shorter DD-initiated KPD chains, longer chains increase the number of KPD transplants by up to 5% and reduce the number of DDs allocated to the KPD pool by 25%. These strategies increase the overall number of blood type O transplants and make LDs available to candidates on the waitlist. Restricting allocation of blood type O DDs to require ending KPD chains with LD blood type O donations to the waitlist markedly reduces the number of KPD transplants achieved.

Conclusion: Allocating fewer than 3% of DD to initiate KPD chains could increase the number of kidney transplants by up to 290 annually. Such use of DDs allows additional transplantation of highly sensitized and blood type O KPD candidates. Collectively, patients of each blood type, including blood type O, would benefit from the proposed strategies.

Keywords: deceased donor; exchange chain; kidney exchange program; kidney paired donation; living donor; nondirected donor.

Grants and funding

R01 DK093513/DK/NIDDK NIH HHS/United States