Hepatitis B RNA and Core-Related Antigen Provide Value Beyond DNA in Evaluating e But Not Surface Antigen Clearance

Wendy C King; Richard K Sterling; Amanda S Hinerman; Anna S F Lok; Gavin A Cloherty; Marc G Ghany; HBRN HBV NOVELASSAYS GROUP

doi:10.1016/j.cgh.2022.06.019

Hepatitis B RNA and Core-Related Antigen Provide Value Beyond DNA in Evaluating e But Not Surface Antigen Clearance

Clin Gastroenterol Hepatol. 2023 Jul;21(7):1957-1959. doi: 10.1016/j.cgh.2022.06.019. Epub 2022 Jul 16.

Authors

Wendy C King¹, Richard K Sterling², Amanda S Hinerman³, Anna S F Lok⁴, Gavin A Cloherty⁵, Marc G Ghany⁶; HBRN HBV NOVELASSAYS GROUP

Collaborators

HBRN HBV NOVELASSAYS GROUP:
Abdus S Wahed⁷, Raymond T Chung⁸, Harry L A Janssen⁹, Mandana Khalili¹⁰, Daryl T Y Lau¹¹, William M Lee¹², Mauricio Lisker-Melman¹³, Norah Terrault¹⁴

Affiliations

¹ Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address: kingw@edc.pitt.edu.
² Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University, Richmond, Virginia.
³ Epidemiology Department, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
⁴ Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan.
⁵ Infectious Disease Research, Abbott Diagnostics, Abbott Park, Illinois.
⁶ Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.
⁷ Biostatistics Department, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
⁸ Hepatology and Liver Center, Massachusetts General Hospital, Boston, Massachusetts.
⁹ Toronto Centre for Liver Disease, University of Toronto, Toronto, Canada.
¹⁰ Division of Gastroenterology and Hepatology, Department of Medicine, University of California San Francisco, San Francisco, California.
¹¹ Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
¹² Liver Disease, UT Southwestern Medical Center, Dallas, Texas.
¹³ Washington University School of Medicine; John Cochran VA Medical Center, St. Louis, Missouri.
¹⁴ Division of Gastrointestinal and Liver Diseases, Keck Medicine of University of Southern California, Los Angeles, California.

PMID: 35850413
PMCID: PMC9841061 (available on 2024-07-01)
DOI: 10.1016/j.cgh.2022.06.019

Abstract

In chronic hepatitis B virus (HBV) infection, hepatitis B e antigen (HBeAg) and hepatitis B surface antigen (HBsAg) clearance are important milestones toward immune control.¹ A drop in HBV DNA is an established correlate of both HBeAg and HBsAg clearance.² We evaluated changes in HBV RNA and hepatitis B core-related antigen (HBcrAg) levels, markers of transcriptional activity of covalently closed circular DNA (cccDNA),^3,4 with HBeAg and HBsAg clearance, and compared them with changes in HBV DNA level among adult participants in the Hepatitis B Research Network (HBRN).

MeSH terms

Adult
Antigens, Surface / therapeutic use
Antiviral Agents / therapeutic use
Biomarkers
DNA, Circular / therapeutic use
DNA, Viral
Hepatitis B Core Antigens
Hepatitis B Surface Antigens / genetics
Hepatitis B e Antigens
Hepatitis B virus / genetics
Hepatitis B* / drug therapy
Hepatitis B, Chronic* / drug therapy
Humans
RNA / therapeutic use

Substances

Hepatitis B Surface Antigens
Hepatitis B e Antigens
DNA, Viral
Antigens, Surface
RNA
Hepatitis B Core Antigens
DNA, Circular
Biomarkers
Antiviral Agents

Abstract

MeSH terms

Substances

Grants and funding