Genetic and environmental variation impact transferability of polygenic risk scores

Daniel S Araújo; Heather E Wheeler

doi:10.1016/j.xcrm.2022.100687

Genetic and environmental variation impact transferability of polygenic risk scores

Cell Rep Med. 2022 Jul 19;3(7):100687. doi: 10.1016/j.xcrm.2022.100687.

Authors

Daniel S Araújo¹, Heather E Wheeler²

Affiliations

¹ Program in Bioinformatics, Loyola University Chicago, Chicago, IL 60660, USA.
² Program in Bioinformatics, Loyola University Chicago, Chicago, IL 60660, USA; Department of Biology, Loyola University Chicago, Chicago, IL 60660, USA. Electronic address: hwheeler1@luc.edu.

Abstract

Even when polygenic risk scores (PRSs) are trained in African ancestral populations, Kamiza and colleagues showed that genetic and environmental variation within sub-Saharan African populations impacts prediction performance, highlighting the challenges of clinical implementation of PRSs for risk assessment.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Black People
Genetic Predisposition to Disease* / genetics
Humans
Multifactorial Inheritance* / genetics
Risk Assessment
Risk Factors

Grants and funding

R15 HG009569/HG/NHGRI NIH HHS/United States