Examining Treatment Outcomes Across Contexts: How Do Child Baseline Characteristics Impact Measurement of Treatment Response?

Rebecca Grzadzinski; Alapika Jatkar; Kevin Donovan; Kinh Truong; Alison Holbrook; Catherine Lord; So Hyun Kim

doi:10.1007/s10803-022-05655-3

Examining Treatment Outcomes Across Contexts: How Do Child Baseline Characteristics Impact Measurement of Treatment Response?

J Autism Dev Disord. 2023 Nov;53(11):4121-4131. doi: 10.1007/s10803-022-05655-3. Epub 2022 Aug 15.

Authors

Rebecca Grzadzinski^{1

2}, Alapika Jatkar¹, Kevin Donovan³, Kinh Truong⁴, Alison Holbrook⁵, Catherine Lord⁶, So Hyun Kim⁷

Affiliations

¹ Carolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, NC, USA.
² Program for Early Autism Research Leadership and Service (PEARLS), University of North Carolina, Chapel Hill, NC, USA.
³ Penn Statistics in Imaging and Visualization Endeavor (PennSIVE), Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
⁴ Gillings School of Global Public Health, Department of Biostatistics, Chapel Hill, USA.
⁵ The Simons Foundation, New York, NY, USA.
⁶ Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, USA.
⁷ School of Psychology, Korea University, Seoul, South Korea. Sok2015@med.cornell.edu.

Abstract

The evaluation of the overlap between the ADOS BOSCC and Standard BOSCC as well as the exploration of child characteristics that may predict change are important steps in consolidating data-driven definitions of "improvement". Participants were seen between 2 and 5 times with Standard BOSCC and ADOS BOSCC observations over the course of early intervention trials (Grzadzinski et al. in J Autism Dev Disord 46:2464, 2016; Kim et al. in Autism 23:5, 2019). Results showed consistency between the Standard BOSCC and ADOS BOSCC, highlighting the utility of both as metrics of change and treatment outcome across contexts. Baseline characteristics may play a role in the tailoring of early intervention to maximize treatment outcome and may offer guidance when determining which outcome measures to use.

Keywords: Autism spectrum disorder (ASD); Brief Observation of Social Communication Change (BOSCC); Early intervention; Treatment outcome.

MeSH terms

Autism Spectrum Disorder* / diagnosis
Autism Spectrum Disorder* / therapy
Autistic Disorder* / diagnosis
Autistic Disorder* / therapy
Child
Early Intervention, Educational
Humans
Outcome Assessment, Health Care
Treatment Outcome

Abstract

MeSH terms

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