Postoperative kinetics of pentraxin 3 (PTX3) after congenital heart surgery with cardiopulmonary bypass in pediatric patients

Radoslaw Jaworski; Katarzyna Dzierzanowska-Fangrat; Renata Grzywa-Czuba; Andrzej Kansy

doi:10.1186/s13741-022-00269-w

Postoperative kinetics of pentraxin 3 (PTX3) after congenital heart surgery with cardiopulmonary bypass in pediatric patients

Perioper Med (Lond). 2022 Aug 22;11(1):35. doi: 10.1186/s13741-022-00269-w.

Authors

Radoslaw Jaworski¹, Katarzyna Dzierzanowska-Fangrat², Renata Grzywa-Czuba³, Andrzej Kansy⁴

Affiliations

¹ Department of Anesthesiology and Intensive Care, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland.
² Department of Clinical Microbiology and Immunology, The Children's Memorial Health Institute, Warsaw, Poland.
³ Department of Clinical Microbiology and Immunology, The Children's Memorial Health Institute, Warsaw, Poland. r.grzywa@ipczd.pl.
⁴ Department of Cardiothoracic Surgery, The Children's Memorial Health Institute, Warsaw, Poland.

Abstract

Background: Pentraxins are inflammatory proteins and markers of acute-phase responses. They are divided into short and long subgroups based on the length of the N-terminal region. The most studied short pentraxin is the C-reactive protein (CRP), which is known to be expressed in various inflammatory conditions, including surgical procedures. On the other hand, much less is known about the kinetics of long pentraxin 3 (PTX3) in surgical patients, especially in the pediatric population. The aim of this prospective study was to determine the early postoperative kinetics of PTX3 in relation to procalcitonin (PCT) and CRP levels in children undergoing congenital heart surgery with cardiopulmonary bypass (CPB).

Methods: A total of 21 children (9 boys and 12 girls, mean age 12 months) were included in the study. Blood samples for determination of CRP, PCT, and PTX3 levels were collected before the surgery and then immediately after its completion (postoperative day 0, POD 0) and subsequently at POD 1, 2, and 3.

Results: Serum PTX3 concentrations increased significantly between POD 0 and POD 1 (mean values were 12.2 and 72.4 ng/ml, respectively, p<0.001), decreased between POD 1 and POD 2 (mean values were 72.4 and 23.6 ng/ml, respectively, p<0.001), and normalized on POD 3 (the mean value was 1.2 ng/ml).

Conclusions: PTX3 concentrations are markedly elevated during the first postoperative day. Under normal circumstances, PTX3 rises and falls quickly, and its second rise in the early postoperative period may be abnormal, however, further studies are necessary.

Keywords: C-reactive protein; Cardiopulmonary bypass; PTX3; Pediatric cardiac surgery; Pentraxin; Procalcitonin; Radoslaw Jaworski and Katarzyna Dzierzanowska-Fangrat have contributed equally to this work and share first authorship..