Epidemiology conduction of paediatric rheumatic diseases based on the registry database of the Pediatric Rheumatology Association of Japan

Hidehiko Narazaki; Shinji Akioka; Yuko Akutsu; Mariko Araki; Mikiya Fujieda; Daisuke Fukuhara; Ryoki Hara; Kunio Hashimoto; Seira Hattori; Ren Hayashibe; Tomoyuki Imagawa; Yuzaburo Inoue; Hiroyuki Ishida; Shuici Ito; Yasuhiko Itoh; Tomohiro Kawabe; Toshiyuki Kitoh; Ichiro Kobayashi; Tadashi Matsubayashi; Takako Miyamae; Mao Mizuta; Masaaki Mori; Ayako Murase; Yasuo Nakagishi; Koji Nagatani; Naoko Nakano; Toyoki Nishimura; Tomo Nozawa; Nami Okamoto; Yuka Okura; Hiromi Sawada; Emi Sawanobori; Yuko Sugita; Yujiro Tanabe; Minako Tomiita; Ken-Ichi Yamaguchi; Ryuhei Yasuoka; Koji Yokoyama

doi:10.1093/mr/roac112

Epidemiology conduction of paediatric rheumatic diseases based on the registry database of the Pediatric Rheumatology Association of Japan

Mod Rheumatol. 2023 Aug 25;33(5):1021-1029. doi: 10.1093/mr/roac112.

Authors

Hidehiko Narazaki^{1

2}, Shinji Akioka³, Yuko Akutsu⁴, Mariko Araki⁵, Mikiya Fujieda⁵, Daisuke Fukuhara⁶, Ryoki Hara⁷, Kunio Hashimoto⁸, Seira Hattori⁷, Ren Hayashibe⁷, Tomoyuki Imagawa^{1

9}, Yuzaburo Inoue^{1

10

11}, Hiroyuki Ishida¹², Shuici Ito⁷, Yasuhiko Itoh², Tomohiro Kawabe¹³, Toshiyuki Kitoh¹⁴, Ichiro Kobayashi¹⁵, Tadashi Matsubayashi¹⁶, Takako Miyamae¹³, Mao Mizuta¹⁷, Masaaki Mori^{18

19}, Ayako Murase⁷, Yasuo Nakagishi¹⁷, Koji Nagatani²⁰, Naoko Nakano²¹, Toyoki Nishimura²², Tomo Nozawa⁷, Nami Okamoto^{23

24}, Yuka Okura¹⁵, Hiromi Sawada²⁵, Emi Sawanobori²⁶, Yuko Sugita²³, Yujiro Tanabe², Minako Tomiita^{11

27}, Ken-Ichi Yamaguchi^{1

28}, Ryuhei Yasuoka²⁹, Koji Yokoyama³⁰

Affiliations

¹ Committee on Patient Registries System, Pediatric Rheumatology Association of Japan, Kyoto, Japan.
² Department of Pediatrics, Nippon Medical School, Tokyo, Japan.
³ Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan.
⁴ Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
⁵ Department of Pediatrics, Kochi Medical School, Kochi University, Kochi, Japan.
⁶ Department of Pediatrics, Kyorin University School of Medicine, Tokyo, Japan.
⁷ Department of Pediatrics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
⁸ Department of Pediatrics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
⁹ Department of Infection and Immunology, Kanagawa Children's Medical Center, Yokohama, Japan.
¹⁰ Department of General Medical Science, Graduate School of Medicine, Chiba University, Chiba, Japan.
¹¹ Department of Allergy and Rheumatology, Chiba Children's Hospital, Chiba, Japan.
¹² Department of Pediatrics, Kyoto City Hospital, Kyoto, Japan.
¹³ Department of Pediatric Rheumatology, Institute of Rheumatology, Tokyo Women's Medical University Hospital, Tokyo, Japan.
¹⁴ Laboratory of Pediatrics, Aichi Gakuin University, School of Pharmacy, Nagoya, Japan.
¹⁵ Center for Pediatric Allergy and Rheumatology, KKR Sapporo Medical Center, Sapporo, Japan.
¹⁶ Seirei Hamamatsu General Hospital, Shizuoka, Japan.
¹⁷ Department of Pediatric Rheumatology, Hyogo Prefectural Kobe Children's Hospital, Kobe, Japan.
¹⁸ Department of Lifetime Clinical Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
¹⁹ Division of Rheumatology and Allergology, St. Marianna University School of Medicine, Kawasaki, Japan.
²⁰ Department of Pediatrics, Uwajima City Hospital, Ehime, Japan.
²¹ Department of Pediatrics, Ehime Prefectural Central Hospital, Ehime, Japan.
²² Division of Pediatrics, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
²³ Department of Pediatrics, Osaka Medical and Pharmaceutical University, Osaka, Japan.
²⁴ Department of Pediatrics, Osaka Rosai Hospital, Osaka, Japan.
²⁵ Tokyo West Tokushukai Hospital, Tokyo, Japan.
²⁶ Department of Pediatrics, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
²⁷ Center of Pediatric Allergy and Rheumatology, National Hospital Organization Shimoshizu National Hospital, Chiba, Japan.
²⁸ Immuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan.
²⁹ Department of Pediatrics, Hamamatsu University School of Medicine, Shizuoka, Japan.
³⁰ Japanese Red Cross Wakayama Medical Center, Wakayama, Japan.

PMID: 36112493
DOI: 10.1093/mr/roac112

Abstract

Objectives: Although epidemiological surveys of paediatric rheumatic diseases in Japan have been conducted, they were single surveys with no continuity. This is the first report of the Pediatric Rheumatology Association of Japan registry database, which was established to continuously collect data for paediatric rheumatic diseases.

Methods: Pediatric Rheumatology International Collaborate Unit Registry version 2 (PRICUREv2) is a registry database established by the Pediatric Rheumatology Association of Japan. The registry data were analysed for the age of onset, time to diagnosis, sex differences, seasonality, and other factors.

Results: Our data showed the same trend regarding rates of paediatric rheumatic diseases reported in Japan and other countries. The age of onset was lower in juvenile idiopathic arthritis (JIA) and juvenile dermatomyositis and higher in systemic lupus erythematosus and Sjögren's syndrome. The time to diagnosis was relatively short in JIA and systemic lupus erythematosus but longer in juvenile dermatomyositis and Sjögren's syndrome. Rheumatoid factor-positive polyarticular JIA showed a seasonality cluster with regard to onset.

Conclusion: PRICUREv2 aided the retrieval and evaluation of current epidemiological information on patients with paediatric rheumatic diseases. It is expected that the data collection will be continued and will be useful for expanding research in Japan.

Keywords: Epidemiology; Japan; paediatrics; registry; rheumatology.

MeSH terms

Arthritis, Juvenile* / epidemiology
Child
Dermatomyositis* / diagnosis
Dermatomyositis* / epidemiology
Female
Humans
Japan / epidemiology
Lupus Erythematosus, Systemic* / diagnosis
Lupus Erythematosus, Systemic* / epidemiology
Male
Registries
Rheumatic Diseases* / epidemiology
Rheumatology*
Sjogren's Syndrome* / diagnosis
Sjogren's Syndrome* / epidemiology