Pancreatic Adenocarcinoma: Trends in Epidemiology, Risk Factors, and Outcomes

Elham Afghani; Alison P Klein

doi:10.1016/j.hoc.2022.07.002

Pancreatic Adenocarcinoma: Trends in Epidemiology, Risk Factors, and Outcomes

Hematol Oncol Clin North Am. 2022 Oct;36(5):879-895. doi: 10.1016/j.hoc.2022.07.002. Epub 2022 Sep 23.

Authors

Elham Afghani¹, Alison P Klein²

Affiliations

¹ Johns Hopkins School of Medicine, 1830 E Monument Street, Room 436, Baltimore, MD 21205, USA.
² Johns Hopkins School of Medicine, 1830 E Monument Street, Room 436, Baltimore, MD 21205, USA; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Johns Hopkins Bloomberg School of Public Health, 1550 Orleans Street, Baltimore, MD 21231, USA. Electronic address: aklein1@jhmi.edu.

Abstract

Pancreatic cancer is one of the most lethal cancers in the world; it is a silent disease in which symptoms do not present until advanced stages, thereby reducing the 5-year survival rate to 10%. The global burden of pancreatic cancer has doubled over the past 25 years despite advancements in medicine. This review aims to discuss the global trends and disparities in pancreatic cancer, as well as the up-to-date literature on the known risk factors. A better understanding of these risk factors will reduce mortality by providing opportunities to screen these patients as well as counseling on lifestyle modifications.

Keywords: Epidemiology; Pancreatic Adenocarcinoma; Pancreatic cancer; Risk Factors; Trend.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adenocarcinoma* / epidemiology
Adenocarcinoma* / therapy
Humans
Pancreatic Neoplasms* / diagnosis
Pancreatic Neoplasms* / epidemiology
Pancreatic Neoplasms* / therapy
Risk Factors
Survival Rate

Abstract

Publication types

MeSH terms

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