From signal to alert: A cluster of exposures to counterfeit alprazolam tablets containing five novel benzodiazepines

Emerg Med Australas. 2023 Feb;35(1):165-167. doi: 10.1111/1742-6723.14108. Epub 2022 Oct 22.

Abstract

Objective: To illustrate the toxicosurveillance role of the Emerging Drugs Network of Australia - Victoria (EDNAV) project in informing timely harm minimisation interventions.

Methods: Utilisation of an ethics approved clinical registry storing de-identified clinical and analytical data on Victorian ED illicit drug-related presentations.

Results: In April 2022, six adults presented to hospital with varying levels of sedation, following the use of counterfeit benzodiazepines. Comprehensive toxicological analysis identified five separate novel benzodiazepines within blood samples from each patient. A public 'Drug Alert' was subsequently issued, and local emergency physicians were notified.

Conclusion: Toxicosurveillance projects, such as EDNAV, are critical to the continued monitoring and reporting of illicit substance use in the community.

Keywords: early warning system; novel benzodiazepines; novel psychoactive substances; toxicosurveillance.

MeSH terms

  • Adult
  • Alprazolam
  • Benzodiazepines*
  • Humans
  • Substance-Related Disorders*
  • Tablets
  • Victoria

Substances

  • Benzodiazepines
  • Alprazolam
  • Tablets