N-(3-chloropropyl)phenylethylamine as a possible prodrug of beta-phenylethylamine: studies in the rat brain

Prog Neuropsychopharmacol Biol Psychiatry. 1987;11(2-3):301-8. doi: 10.1016/0278-5846(87)90074-1.

Abstract

N-(3-Chloropropyl)phenylethylamine (CPPEA) was examined as a possible prodrug of the neuromodulator trace amine beta-phenylethylamine (PEA) in rat tissues. CPPEA produced sustained elevation of PEA levels in rat brain, blood and liver. Rat brain concentrations of noradrenaline, dopamine and 5-hydroxytryptamine were decreased by administration of CPPEA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / drug effects*
  • Brain / metabolism
  • Kinetics
  • Liver / drug effects
  • Liver / metabolism
  • Male
  • Phenethylamines / metabolism*
  • Phenethylamines / pharmacology*
  • Rats
  • Rats, Inbred Strains

Substances

  • Phenethylamines
  • N-(3-chloropropyl)phenylethylamine
  • phenethylamine