Successful pregnancy in a cystic fibrosis patient with a severe impairment of lung function receiving Elexacaftor-Tezacaftor-Ivacaftor

Zisis Balmpouzis; Annabelle Faure van Rossum; David Baud; Alice Panchaud; Georgia Mitropoulou; Jesica Mazza Stalder; Angela Koutsokera

doi:10.1016/j.rmcr.2022.101776

Successful pregnancy in a cystic fibrosis patient with a severe impairment of lung function receiving Elexacaftor-Tezacaftor-Ivacaftor

Respir Med Case Rep. 2022 Nov 8:40:101776. doi: 10.1016/j.rmcr.2022.101776. eCollection 2022.

Authors

Zisis Balmpouzis^{1

2}, Annabelle Faure van Rossum³, David Baud⁴, Alice Panchaud^{5

6}, Georgia Mitropoulou^{1

2}, Jesica Mazza Stalder¹, Angela Koutsokera^{1

2}

Affiliations

¹ Adult Cystic Fibrosis and CFTR-related Disorders Center, Division of Pulmonology, Dept of Medicine, Lausanne University Hospital and University of Lausanne, Switzerland.
² Lung Transplant Center, Division of Pulmonology, Dept of Medicine, Lausanne University Hospital and University of Lausanne, Switzerland.
³ Operative Gynecology and Obstetrics, Private Practice, Switzerland.
⁴ Materno-fetal and Obstetrics Research Unit, Department Woman-Mother-Child, Lausanne University Hospital, 1011, Lausanne, Switzerland.
⁵ Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.
⁶ Service of Pharmacy, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Abstract

Before the arrival of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) modulators women with CF and impaired lung function were experiencing a high risk of complications and mortality during and the years after pregnancy. The arrival of the highly efficient CFTR modulator, Elexacaftor-Tezacaftor-Ivacaftor (ETI) resulted in an improvement of lung function, quality of life and fertility. Here we report a case of successful pregnancy and uncomplicated delivery for a CF patient with severely impaired lung function receiving ETI prior to conception.

Keywords: Cystic fibrosis; Elexacaftor-Tezacaftor-Ivacaftor; Impaired lung function; Pregnancy.

Publication types

Case Reports