Acute pancreatitis following L-asparaginase in acute lymphoblastic leukemia

Soulaimane M'harzi; Aziza Elouali; Karim Lahrache; Ayad Ghanam; Abdeladim Babakhouya; Maria Rkain; Noufissa Benajiba

doi:10.1016/j.lrr.2022.100357

Acute pancreatitis following L-asparaginase in acute lymphoblastic leukemia

Leuk Res Rep. 2022 Nov 9:18:100357. doi: 10.1016/j.lrr.2022.100357. eCollection 2022.

Authors

Soulaimane M'harzi^{1

2}, Aziza Elouali^{1

2}, Karim Lahrache^{1

2}, Ayad Ghanam^{1

2}, Abdeladim Babakhouya^{1

2}, Maria Rkain², Noufissa Benajiba^{1

2}

Affiliations

¹ Faculty of Medicine and Pharmacy of Oujda, Mohammed I University of Oujda, Morocco.
² Department of Pediatrics, Mohammed VI University Hospital of Oujda, Morocco.

Abstract

Acute lymphoblastic leukemia (ALL) is the most frequent malignancy in children,representing 25-30% of all childhood malignancies. Although treatment outcome has improved owing to advances in chemotherapy, there is still a group of patients who experience severe adverse events. L-Asparaginase is an effective antineoplastic agent used in chemotherapy of ALL. Despite its indisputable indication, it can cause various adverse effects, including acute pancreatitis (AP). Recently, an increase in the number of pediatric AP cases following L-Asparaginase in Acute Lymphoblastic Leukemia been reported. We presented a case of acute pancreatitis in children with ALL induced by administration of L-ASPA preparations.

Keywords: ALL; Acute pancreatitis; L-asparaginase.

Publication types

Case Reports