Deep immune profiling uncovers novel associations with clinical phenotypes of multisystem inflammatory syndrome in children (MIS-C)

Christopher John Redmond; Moses M Kitakule; Aran Son; McKella Sylvester; Keith Sacco; Ottavia Delmonte; Francesco Licciardi; Riccardo Castagnoli; M Cecilia Poli; Yasmin Espinoza; Camila Astudillo; Sarah E Weber; Gina A Montealegre Sanchez; Karyl S Barron; Mary Magliocco; Kerry Dobbs; Yu Zhang; Helen Matthews; Cihan Oguz; Helen C Su; Luigi D Notarangelo; Pamela Frischmeyer-Guerrerio; Daniella M Schwartz

doi:10.1136/ard-2022-223269

Deep immune profiling uncovers novel associations with clinical phenotypes of multisystem inflammatory syndrome in children (MIS-C)

Ann Rheum Dis. 2023 Mar;82(3):442-445. doi: 10.1136/ard-2022-223269. Epub 2022 Nov 24.

Authors

Christopher John Redmond¹, Moses M Kitakule², Aran Son³, McKella Sylvester⁴, Keith Sacco^{5

6}, Ottavia Delmonte⁷, Francesco Licciardi⁸, Riccardo Castagnoli⁷, M Cecilia Poli⁹, Yasmin Espinoza¹⁰, Camila Astudillo¹⁰, Sarah E Weber¹¹, Gina A Montealegre Sanchez¹², Karyl S Barron¹³, Mary Magliocco¹¹, Kerry Dobbs⁷, Yu Zhang¹⁴, Helen Matthews¹⁴, Cihan Oguz¹⁵, Helen C Su¹⁴, Luigi D Notarangelo⁷, Pamela Frischmeyer-Guerrerio³, Daniella M Schwartz^{3

16}

Affiliations

¹ Vasculitis Translational Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA redmondchj@nih.gov.
² Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
³ Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
⁴ Vasculitis Translational Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA.
⁵ National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
⁶ Department of Allergy and Immunology, University of Arizona, Phoenix, Arizona, USA.
⁷ Immune Deficiency and Genetics Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
⁸ Dipartimento di Scienze della Sanità Pubblica e Pediatrica, Università degli Studi di Torino, Torino, Italy.
⁹ Department of Pediatrics, Facultad de Medicina Clinica Alemana Universidad del Desarrollo, Santiago, Chile.
¹⁰ Hospital Roberto del Rio, Santiago, Chile.
¹¹ Molecular Development of the Immune System Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
¹² Translational Autoinflammatory Diseases Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
¹³ Office of the Scientific Director, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
¹⁴ Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
¹⁵ Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
¹⁶ Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.

No abstract available

Keywords: Covid-19; Immune System Diseases; Inflammation.

Publication types

Research Support, N.I.H., Intramural

MeSH terms

COVID-19*
Humans
Systemic Inflammatory Response Syndrome*

Supplementary concepts

pediatric multisystem inflammatory disease, COVID-19 related

Publication types

MeSH terms

Supplementary concepts

Grants and funding