The many genomes of Parkinson's disease

Haydeh Payami

doi:10.1016/bs.irn.2022.07.007

The many genomes of Parkinson's disease

Int Rev Neurobiol. 2022:167:59-80. doi: 10.1016/bs.irn.2022.07.007. Epub 2022 Aug 11.

Author

Haydeh Payami¹

Affiliation

¹ Professor of Genetics and Neurology, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, United States; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, United States. Electronic address: haydehpayami@yahoo.com.

PMID: 36427959
DOI: 10.1016/bs.irn.2022.07.007

Abstract

Genetic component of Parkinson's disease, once firmly believed non-existent, involves the human genome, mitochondrial genome, and the microbiome. Understanding the genomics of PD requires identification of PD-relevant genes and learning how they interact within the hologenome and with their environment. This chapter is an evidence-based perspective of a geneticist on how far we have come in this endeavor. The contemporary scientific society started with a naive and simplistic view of PD, evolved to accept that Parkinson's disease is probably the most complex disease there is, the progress we have made in discovering the genes and elucidating their functions, and now assembling the parts to create the whole.

Keywords: Holobiont; Hologenome; Human genome; Metagenomics; Microbiome; Mitochondrial genome; Parkinson's disease.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Microbiota*
Parkinson Disease* / genetics