Cardiopulmonary Exercise Testing in Pulmonary Arterial Hypertension

Alexander E Sherman; Rajan Saggar

doi:10.1016/j.hfc.2022.08.015

Cardiopulmonary Exercise Testing in Pulmonary Arterial Hypertension

Heart Fail Clin. 2023 Jan;19(1):35-43. doi: 10.1016/j.hfc.2022.08.015.

Authors

Alexander E Sherman¹, Rajan Saggar²

Affiliations

¹ Division of Pulmonary, Critical Care, Sleep Medicine, Clinical Immunology and Allergy, David Geffen School of Medicine at UCLA, 650 Charles East Young Drive South 43-229 CHS, Los Angeles, CA 90095-1690, USA. Electronic address: asherman@mednet.ucla.edu.
² Division of Pulmonary, Critical Care, Sleep Medicine, Clinical Immunology and Allergy, David Geffen School of Medicine at UCLA, 650 Charles East Young Drive South 43-229 CHS, Los Angeles, CA 90095-1690, USA; Pulmonary Hypertension Program, Pulmonary Vascular Disease Program, Lung & Heart-Lung Transplant and Pulmonary Hypertension Programs, Pulmonary and Critical Care Division, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

PMID: 36435571
DOI: 10.1016/j.hfc.2022.08.015

Abstract

Cardiopulmonary exercise testing (CPET) is a comprehensive methodology well studied in pulmonary arterial hypertension (PAH) with roles in diagnosis, treatment response, and prognosis. Submaximal and maximal exercise data is a valuable tool in detecting abnormal hemodynamics associated with exercise-induced and resting pulmonary hypertension as well as right ventricular dysfunction. The increased granularity of CPET may help further risk stratify patients to inform prognosis and better individualize treatment decisions. This article reviews the most commonly implicated variables from CPET in PAH literature and summarizes the latest developments in CPET and exercise testing.

Keywords: CPET; Cardiopulmonary exercise test; Pulmonary arterial hypertension; Pulmonary hypertension.

Publication types

Review

MeSH terms

Exercise / physiology
Exercise Test / methods
Exercise Tolerance / physiology
Humans
Hypertension, Pulmonary*
Pulmonary Arterial Hypertension* / diagnosis