Cancer risk among HIV-exposed uninfected children in the United States

AIDS. 2023 Mar 1;37(3):549-551. doi: 10.1097/QAD.0000000000003458. Epub 2022 Dec 22.

Abstract

In utero exposure to didanosine was associated with increased risk of brain cancer in a French study. We used United States health department records to assess cancer risk among 13 617 children exposed to HIV in utero , who remained HIV-uninfected after birth (1990-2017). Risk of brain tumors was borderline elevated among these children (standardized incidence ratio 2.2, 95% confidence interval 0.8-4.8, P = 0.12, based on six cases). Risk was not significantly increased for leukemia or other cancers.

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Anti-HIV Agents* / therapeutic use
  • Child
  • Female
  • HIV Infections* / complications
  • HIV Infections* / drug therapy
  • Humans
  • Infant
  • Neoplasms* / drug therapy
  • Neoplasms* / epidemiology
  • Pregnancy
  • Pregnancy Complications, Infectious* / drug therapy
  • Prenatal Exposure Delayed Effects* / chemically induced
  • Prenatal Exposure Delayed Effects* / epidemiology
  • Prospective Studies
  • United States / epidemiology

Substances

  • Anti-HIV Agents